Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
By Rute Martins, G. Lithgow, W. Link. Aging Cell, 2015
672 citations recorded by the source corpus.
Aging constitutes the key risk factor for age‐related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors. The fact that genetic contribution to lifespan strongly increases with greater age provides basis for research on which “protective genes” are carried by long‐lived individuals. Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity. FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin‐like growth factor signaling. Invertebrate genomes have one FOXO gene, while mammals have four FOXO genes: FOXO1, FOXO3, FOXO4, and FOXO6. In mammals, this subfamily is involved in a wide range of crucial cellular processes regulating stress resistance, metabolism, cell cycle arrest, and apoptosis. Their role in longevity determination is complex and remains to be fully elucidated. Throughout this review, the mechanisms by which FOXO factors contribute to longevity will be discussed in diverse animal models, from Hydra to mammals. Moreover, compelling evidence of FOXOs as contributors for extreme longevity and health span in humans will be addressed.
Subfields: Aging, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8c4b8af2c5b47bf03b10beb6bf1ee06df1fa7608
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In Aging
In Molecular Biology
- Jeroen Essers
- J. Campisi
- Jan H. J. Hoeijmakers
- W. V. van Cappellen
- Erik H. W. Meijering
- M. Demaria
- Jesús Gil
- Alan Ashworth
Citations in the corpus
- Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017, background): “FOXOs are well studied in aging and tissue homeostasis as targets of insulin/ IGF signaling and as regulators of reactive oxygen species (de Keizer et al., 2011; Eijkelenboom and Burgering, 2013; Martins et al., 2016).”