Control of synapse number by glia.
By E. Ullian, S. Sapperstein, K. S. Christopherson, B. Barres. Science, 2001
1,388 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/6e5e53724046e5d181325604f2b8d3354e341c2e
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In Cellular and Molecular Neuroscience
In Developmental Neuroscience
In Neurology
Citations in the corpus
- Astrocytes and disease: a neurodevelopmental perspective. (2012, background): “In a series of studies from the Barres laboratory (Pfrieger and Barres 1997; Ullian et al. 2001), it was first demonstrated that purified retinal ganglion cells make many more synapses when cocultured with astrocytes, even in the absence of direct contact, which suggested the presence of a secreted ”
- Astroglia induce neurogenesis from adult neural stem cells (2002, background): “For example, astrocytes have been reported to induce and/or stabilize CNS synapse”
- Glia: listening and talking to the synapse (2001, background): “This is particularly important if one considers that glia can also regulate the formation of synapse”
- Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains (2002, background): “They are thought to play many important and diverse roles, including guiding development (Hatten and Mason, 1990; Ullian et al., 2001), regulating the extracellular concentrations of ions, metabolites, and neurotransmitters (Walz, 1989; Vernadakis, 1996), and supporting neuronal and synaptic…”
- Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, neutral): “For example, purified neurons in culture have little ability to form functional synapses, which are powerfully promoted by astrocytes (Allen et al., 2012; Christopherson et al., 2005; Kucukdereli et al., 2011; Ullian et al., 2001).”
- The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting (2016, background): “On the contrary, glial cells perform a long list of essential functions (Baumann and Pham-Dinh, 2001; Haydon, 2001; Ullian et al., 2001; Doetsch, 2003; Nedergaard et al., 2003; Allen and Barres, 2009; Fields, 2010; Han et al., 2013; Kettenmann and Ransom, 2013; Verkhratsky and Butt, 2013).”
- Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “However, recent work has revealed that astrocytes are dynamic regulators of many brain processes, including synaptogenesis and synaptic efficacy (Ullian et al. 2001; Phil.”
- The blood-brain barrier: an engineering perspective (2013, background): “An in vitro model of the human BBB should exhibit restricted paracellular transport (TEER = 1 k cm2, Psucrose 10−7 cm s−1), BMECs with the morphology and characteristics typical of the BBB, expression of BBB-specific markers and transporters, and be readily available, convenient to use, and reprod”
- Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons (2002, background): “How efficiently, if at all, can adult neural stem cells give rise to fully functional neurons with essential properties of mature CNS neurons? The mechanisms of differentiation, maturation and synapse formation of neural progenitors during development have been thoroughly investigate”
- Neuregulins: functions, forms, and signaling strategies. (2003, background): “It is clear that NRG signaling is required for the stabilization of neuromuscular synapses [67,68], and evidence for NRG involvement in astrocyte biology might implicate NRGs in formation or stabilization of central synapses [69] (see also [70]).”