The blood-brain barrier: an engineering perspective
By Andrew D. Wong, Mao Ye, Amanda F. Levy, Jeffrey D. Rothstein, D. Bergles, Peter C. Searson. Frontiers in Neuroengineering, 2013
595 citations recorded by the source corpus.
It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a small number of molecules, such as alcohol and caffeine have been found to cross the blood-brain barrier, and this selective permeability remains the major roadblock to treatment of many central nervous system diseases. At the same time, many central nervous system diseases are associated with disruption of the blood-brain barrier that can lead to changes in permeability, modulation of immune cell transport, and trafficking of pathogens into the brain. Therefore, advances in our understanding of the structure and function of the blood-brain barrier are key to developing effective treatments for a wide range of central nervous system diseases. Over the past 10 years it has become recognized that the blood-brain barrier is a complex, dynamic system that involves biomechanical and biochemical signaling between the vascular system and the brain. Here we reconstruct the structure, function, and transport properties of the blood-brain barrier from an engineering perspective. New insight into the physics of the blood-brain barrier could ultimately lead to clinical advances in the treatment of central nervous system diseases.
Subfields: Neurology, Oncology, Physiology
View Paper: https://www.semanticscholar.org/paper/c47039f5e641b820e0e2dd4e69cc8f3bdc641a43
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Citations in the corpus
- 3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “This contrasts with a previous study that reported an increase in permeability coefficient when human brain endothelial cells (hCMEC/d3) were co-cultured with ACs isolated from rats [32], possibly due to cross-species effects, as suggested by the authors of [29].”
- The blood–brain barrier in systemic infection and inflammation (2021, background): “The vascular BBB has the largest surface area among the various interfaces, corresponding to a total surface area of 15–25m(2) [10], and will be hereafter referred to simply as the BBB.”
- TEER measurement techniques for in vitro barrier model systems (2015, background): “The blood–brain barrier (BBB)41 is an active interface between the circulatory system and the CNS that restricts the free movement of different substances between the two compartments and plays a crucial role in maintaining homeostasis in the CNS. Figure 4 (adapted from Wong et al.42) shows a schema”