Microglial priming in neurodegenerative disease

By V. Perry, C. Holmes. Nature Reviews Neurology, 2014

1,068 citations recorded by the source corpus.

Subfields: Immunology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/6e0f1b2c4406e56ba33622ef41de346b6abd120f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Holtzman
2. Hans Lassmann
3. Zhiping Weng
4. Howard L. Weiner
5. I. Galea
6. O. Butovsky
7. A. Varatharaj

In Neurology

1. D. Holtzman
2. I. Galea
3. Hans Lassmann
4. Christian Haass
5. Howard L. Weiner
6. O. Butovsky
7. Oliver D. Howes
8. A. Varatharaj

In Physiology

1. D. Holtzman
2. I. Galea
3. J. Heeren
4. Christian Haass
5. A. Varatharaj
6. J. Long
7. Berislav Zlokovic
8. D. Selkoe

Citations in the corpus

• Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, background): “Microglial priming has been studied in relation to neurodegenerative disorders (Perry and Holmes 2014), and a recent morphometry study has found evidence of increased microglial priming in middleaged patients with depression who died by suicide compared with healthy controls (Torres-Platas et al.…”
• High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (2018, neutral): “Aging is a major risk factor for neurodegenerative diseases, and changes in microglial morphology precede pathology in Alzheimer’s patients (Perry and Holmes, 2014; Streit et al., 2009).”
• The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases (2017, background): “, 2015) and become chronically inflammatory (Perry and Holmes, 2014).”
• Inflammation as a central mechanism in Alzheimer's disease (2018, background): “Microglia are primed in AD brains to be more susceptible to secondary inflammatory insults, resulting in an exacerbated inflammatory response [273].”
• Transcriptomic analysis of purified human cortical microglia reveals age-associated changes (2017, background): “An increased inflammatory signature characterizes the aging and neurodegenerative mouse brain, in which microglia take on a sensitized, primed phenotype 11 .”
• The blood-brain barrier in systemic inflammation. (2017, positive): “An established mechanism is the increased sensitivity to systemic inflammation of primed CNSresident immune cells in these conditions (Perry and Holmes, 2014); this is facilitated by the BBB changes discussed in this review.”