Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

By Thais F. Galatro, I. Holtman, A. Lerário, I. Vainchtein, N. Brouwer, P. Sola, M. Veras, T. F. Pereira, R. Leite, T. Möller and 9 more. Nature Neuroscience, 2017

634 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/8d2b5393ec7f7a363292e5e305e15da374993835

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Ransohoff
2. Marco Prinz
3. Aviv Regev
4. Joachim L. Schultze
5. Martin Hemberg
6. Berislav Zlokovic

In Neurology

1. Marco Prinz
2. R. Ransohoff
3. Julie A. Schneider
4. David A. Bennett
5. Joachim L. Schultze
6. C. Iadecola
7. B. Barres
8. Josef Priller

Citations in the corpus

• Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “clearance, these results suggest that fundamental microglial functions are impaired with age [523].”
• Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution (2017, result): “To this end, we compared our data with a recently published transcriptomic analysis of purified human cortical microglia (Galatro et al., 2017).”
• Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease (2020, methodology): “First, the software was trained to automatically segment the images into: (1) cells (DAPI positive objects); (2) microglial cells (DAPI+/IBA1+ or DAPI+/CD45+ objects); (3) microglial subtypes (DAPI+/ IBA1+/CD83+ and DAPI+/IBA1+/CD83−; DAPI+/IBA1+/PCNA+ and DAPI+/IBA1+/PCNA−; DAPI+/CD45+/ISG15+ and D”
• Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases (2019, background): “The study suggests that with increasing age, microglia downregulate actin cytoskeleton-related genes (TLN1, PFN1, EVL, ARPC1A, ARPC1B, CORO1A, CAP1, CTNNA2, VASP) and cell surface receptors (P2RY12, IL6R, TLR10) (155).”