Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo.

By Y. Fukazawa, Y. Saitoh, F. Ozawa, Y. Ohta, K. Mizuno, K. Inokuchi. Neuron, 2003

764 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/6cd7659522222a0a0f47c327a881f21910341e61

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Citations in the corpus

TrkB signalling pathways in LTP and learning (2009, background): “, and are mediated by changes in the actin cytoskeleto”
Structural plasticity and memory (2004, background): “LTP induction in the dentate gyrus of freely moving adult animals also increases the content of polymerized actin (F-actin) in dendritic spines in the hippocampu”
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, methodology): “Dentate Gyrus LTP in Unanaesthetized Freely Moving Rats Measurement of DG LTP in unanaesthetized freely moving rats has been described previously (Fukazawa et al., 2003; Kato et al., 1997; Matsuo et al., 2000).”
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, neutral): “In keeping with this, LTP induces a lasting increase in polymerized actin in dendritic spines (132), and a reduction in actin-based spine motility underlies spine stabilization (282).”
Molecular mechanisms of dendritic spine morphogenesis. (2006, neutral): “LTP inducing stimulation increases actin polymerization in spines of hippocampal neurons (Figure 1), as shown by actin-GFP FRET experiments [14 ], or by rhodaminephalloidin labeling [22,23].”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, positive): “F-actin polymerization in spines plays a key role in LTP maintenance in vivo (Fukazawa et al., 2003) and, therefore, these alterations may underlie some of the effects of BDNF in long-term synaptic potentiation.”
Dendritic mRNA: transport, translation and function (2007, background): “Actin polymerization is associated with expansion of the PSD and conversion of small, stubby dendritic spines to large mushroom-shaped spine”
Forgetting is regulated through Rac activity in Drosophila. (2010, neutral): “In vertebrates, the actin-depolymerizing activity of cofilin has been shown to be important for synaptic plasticity and activity-dependent modification of spine morphology (Fukazawa et al., 2003; Zhou et al., 2004).”
The role of the Rho GTPases in neuronal development. (2005, background): “Long-lasting increases in F-actin content within dendritic spines, and changes in spine number, size, and shape, which are associated with LTP, are dependent upon NMDA receptor activation and inactivation of ADF/cofilin, an actin depolymerizing protein (Fukazawa et al. 2003).”
Actin in dendritic spines: connecting dynamics to function (2010, background): “During LTP expression, the actin cytoskeleton is stabilized and is resistant to latrunculin A (Ramachandran and Frey, 2009), which has been shown to occur through cofilin inactivation (Fukazawa et al., 2003; Chen et al., 2007; Fedulov et al., 2007).”
The yin and yang of neurotrophin action (2005, background): “and long-lasting enhancement of F-actin content in dendritic spine”
Balancing structure and function at hippocampal dendritic spines. (2008, background): “Induction of LTP briefly depolymerizes actin filaments (Ouyang et al. 2005), whereas maintenance of LTP and sustained spine enlargement require polymerization of F-actin (Kim & Lisman 1999, Krucker et al. 2000, Fukazawa et al. 2003, Lin et al. 2005).”