Forgetting is regulated through Rac activity in Drosophila.

By Yichun Shuai, Binyan Lu, Ying Hu, Lianzhang Wang, Kan Sun, Yi Zhong. 2010

245 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Ecology, Evolution, Behavior and Systematics

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Citations in the corpus

Incorporating neuro-inspired adaptability for continual learning in artificial intelligence (2023, positive): “…of task B. Similarly, the learner needs to find θ ∗ A , B = argmax θ log p ( θ | D A , D B ) , corresponding to maximizing both log p ( D B | θ ) for learning task B and log p ( θ | D A ) for remembering task A. clear and in-depth understanding at both functional and anatomical levels 19–26 (Fig.”
Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila (2022, methodology): “This result is consistent with previous studies on Retro- I (Cervantes- Sandoval et al., 2016; Dong et al., 2016; Gai et al., 2016; Gao et al., 2019; Reaume et al., 2011; Shuai et al., 2010).”
AFEC: Active Forgetting of Negative Transfer in Continual Learning (2021, positive): “Our contributions include: (1) We draw inspirations from the biological active forgetting and propose a novel approach to actively forget the old knowledge that interferes with the learning of new tasks for continual learning; (2) Extensive evaluation on a variety of continual learning benchmarks sh”
Dopamine Is Required for Learning and Forgetting in Drosophila (2012, positive): “These two gal4 drivers share expression in the DAN class of neurons that uniquely innervates theMBheel/ peduncle and intersects with the processes of both a/b and gMB neurons, neurons in which Rac-mediated forgetting has been suggested to occur (Shuai et al., 2010).”
Sleep facilitates memory by blocking dopamine neuron mediated forgetting (2015, unknown): “Even though forgetting is often thought of as a failure or limitation of the brain, recent studies support the view that forgetting is a biologically regulated function of the brain allowing optimal adaptability to an ever-changing environment (Berry and Davis, 2014; Berry et al., 2012; Shuai et al.”
The Persistence and Transience of Memory. (2017, background): “Indeed, ﬂies expressing a mutant form of coﬁlin exhibited reduced forgetting in the odor-shock paradigm, phenocopying the effects of Rac inhibition (Shuai et al., 2010).”
Actin in dendritic spines: connecting dynamics to function (2010, background): “Moreover, a recent re port showed that Rac in mushroom body neurons contributes to both passive memory decay and interferenceinduced forgetting, suggesting that actin reorganization may contribute to memory erasure in Drosophila (Shuai et al., 2010).”
Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. (2019, background): “305 In forgetting, another receptor, Dop1R2 (aka damb), activates Rac1 and Scribbled via a 306 different G protein, Gq [98-100].”
Genetic dissection of active forgetting in labile and consolidated memories in Drosophila (2019, methodology): “Aversive olfactory conditioning was performed as previously described (3, 4).”
Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory (2011, background): “For instance, ASM is specifically affected in mutants with the impaired cAMP/protein kinase A (PKA) signaling pathway (e.g., rutabaga, encoding the type I adenylyl cyclase) (Dudai et al., 1988; Folkers et al., 1993; Isabel et al., 2004; Schwaerzel et al., 2007; Shuai et al., 2010).”
Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace (2018, unknown): “, 1996), Rac1 (Shuai et al., 2010), Scribble (Cervantes-Sandoval et al.”
Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. (2018, unknown): “Consistent with our previous findings (Shuai et al., 2010), Rac1-CA-expressing flies exhibited significantly decreased performance.”
Differential conditioning produces merged long-term memory in Drosophila (2021, methodology): “For cold-shock anesthesia, flies were transferred into pre-chilled plastic vials and kept on ice for 2 min as described previously described (Shuai et al., 2010).”
Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes (2016, background): “Because the activation of the small G protein Rac1 is critical in regulating forgetting and reversal-learning as examined here (20), we compared the activation levels of Rac-GTP in WT and Fmr1 mutant flies immediately after reversal-learning.”
A Normative Theory of Forgetting: Lessons from the Fruit Fly (2014, background): “the concentration of Rac [8] or dopamine [2].”
Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory (2015, methodology): “First, whereas the molecular pathways for learning and forgetting of olfactory aversive memory are distinct and separable (6, 7), the neural circuits seem to overlap.”
Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention. (2016, methodology): “Studies have increasingly focused on the biological 818 Cell Reports 16, 817–825, July 19, 2016 basis of active forgetting using different animal models (Akers et al., 2014; Berry et al., 2012, 2015; Hadziselimovic et al., 2014; Inoue et al., 2013; Shuai et al., 2010, 2015).”