Cancer metabolism: facts, fantasy, and fiction.

By X. Zu, M. Guppy. Biochemical and Biophysical Research Communications - BBRC, 2004

638 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/6cb85cbf8185b8acd6f1a6dc27c36f386eaa38e0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

In Spectroscopy

Citations in the corpus

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited (2010, methodology): “Comparisons to experimental data reported for LS mouse cells [17], hybridoma cells [18] and a collection of normal and cancer cells [4] provide an indirect support for the validity of these predictions.”
Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer (2009, background): “Second, although many tumor cell lines do show high glycolytic rates, the contribution of glycolysis to total cellular ATP content varies widely, from over 50%, as Warburg found, to less than 5% in other cells (Zu and Guppy, 2004).”
Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. (2005, background): “However, whether the increase of glycolytic activity in cancer cells is mainly due to inherent metabolic alterations or due to anaerobic environment in the tumor tissues remains controversial (3).”
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “Since the glycolytic contribution to total ATP production does not generally exceed 50-60% (8), OXPHOS still substantially contributes to ATP production in tumor cells.”
Causes and Consequences of Increased Glucose Metabolism of Cancers (2008, background): “In a careful review of the available data from careful mass balance studies, it was concluded that, on average, cancers derive 17% of their ATP turnover from EMP glycolysis, whereas normal tissues derive around 20% (185).”
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer (2006, background): “Although this apparently anaerobic glycolysis under aerobic conditions is now widely recognized, its biochemical causes and biological consequences in tumours are not (Gatenby and Gillies, 2004; Zu and Guppy, 2004).”
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. (2011, positive): “They are quite active and generate the majority of ATP in many normal and cancer cells (Zu & Guppy 2004).”
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy (2018, background): “A meta-analysis of 16 normal cell types and 31 cancer cell lines indicated that the relative contribution of glycolysis and OXPHOS to ATP production is highly variable between cell types, but that the average contribution of OXPHOS to ATP production is 80% in normal cells and 83% in cancer cells (16”
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases (2009, background): “By comparison, the acid production rate of tumors can be f100 Amol/h/g of tumor weight (45).”
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells (2015, background): “However, despite utilizing aerobic glycolysis, most cancer cells also consume oxygen (Weinhouse, 1956; Zu and Guppy, 2004).”
Targeting Metabolism for Cancer Therapy (2017, background): “However, subsequent work determined that despite engaging in aerobic glycolysis, cancer cells consume oxygen at levels comparable to normal tissue (Weinhouse, 1956; Zu and Guppy, 2004).”
Glycolysis inhibition for anticancer treatment (2006, background): “Although the cause–effect relationship between the increase in aerobic glycolysis and the development of cancer is controversial (Zu and Guppy, 2004), increased glycolysis has been consistently observed in many cancer cells of various tissue origins (for a review, see Semenza et al., 2001),…”
Cancer as a metabolic disease (2010, background): “Considerable controversy has surrounded the issue of mitochondrial function in cancer cells [18,29,30,33,34,51-57].”
Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “While ATP generation is broadly attributed to mitochondrial respiration in cancer cells for instance, both cell type and conditional context can affect glycolytic contributions to ATP production by up to two orders of magnitude (72).”