Targeting Metabolism for Cancer Therapy

By Alba Luengo, D. Y. Gui, M. V. Vander Heiden. Cell Chemical Biology, 2017

787 citations recorded by the source corpus.

Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have been effective cancer treatments for decades, and the success of these therapies demonstrates that a therapeutic window exists to target malignant metabolism. New insights into the differential metabolic dependencies of tumors have provided novel therapeutic strategies to exploit altered metabolism, some of which are being evaluated in pre-clinical models or clinical trials. Here, we review our current understanding of cancer metabolism and discuss how this might guide treatments targeting the metabolic requirements of tumor cells.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6ae9d328918aa4a2bdd3485419bdd5d6d3ba05f1

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Citations in the corpus

• Lipid metabolism reprogramming and its potential targets in cancer (2018, background): “It is converted to pyruvate through glycolysis, and enters mitochondria to form citrate, which is then released into the cytoplasm to serve as a precursor for the synthesis of both fatty acids and cholesterol [47, 48].”
• Cuproptosis: mechanisms and links with cancers (2023, background): “Tumor cells treated with certain antitumor drugs such as proteasome inhibitors(PI) have also been found to exhibit higher mitochondrial metabolism [14, 15].”