REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.

By N. Ballas, C. Grunseich, Diane D. A. Lu, J. Speh, G. Mandel. Cell, 2005

947 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d0c1c2ee62942ffbfb8037a365772048627cce5e

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Citations in the corpus

Genome-wide identification of in vivo protein–DNA binding sites from ChIP-Seq data (2008, background): “…insulator protein CTCF (CCCTC-binding factor) (7–11), NRSF (neuron-restrictive silencer factor) (also known as REST, for repressor element-1 silencing transcription factor) (12– 15) and transcription activator protein STAT1 (signal transducer and activator of transcription protein 1) (16– 19).”
Core transcriptional regulatory circuitry in human embryonic stem cells. (2005, background): “For instance, REST has recently been shown to be highly abundant in ES cells and functions in part to repress neuronal specific genes (Ballas et al., 2005).”
Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs (2010, background): “miRNAs have been described as potential regulators of self renewal [48], plasticity [49] and differentiation potential of many stem cell types including MSCs [50,51,52].”
The bi-functional microRNA miR-9/miR-9* regulates REST and CoREST and is down-regulated in Huntington’s Disease (2008, background): “REST expression is highest in pluripotent stem cells and decreases upon restriction to neural progenitor cells and subsequently to neurons (Ballas et al., 2005).”
Genome-Wide Analysis of Transcription Factor Binding Sites Based on ChIP-Seq Data (2008, neutral): “GABP (GA-binding protein) and SRF (serum response factor) are thought to function primarily as transcriptional activators12–18, whereas NRSF (neuron-restrictive silencer factor) is a transcriptional repressor19,20.”
A Nurr1/CoREST transrepression pathway attenuates neurotoxic inflammation in activated microglia and astrocytes (2009, positive): “These studies thus establish an unexpected biological role for the CoREST complex, previously considered to mainly be involved in the repression of neuronal genes in NSCs or nonneuronal cells (Ballas et al., 2005).”
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. (2007, background): “The fact that brain-enriched miRNAs tend to target brain-enriched genes suggests that some of them may be positively coregulated by transcription factors that specify neuronal fates (e.g., NRSF/REST [Ballas et al., 2005]; see the Discussion).”
Mouse and rat BDNF gene structure and expression revisited (2006, background): “…cofactors including HDAC1, HDAC2, and mSin3A (for review see Ballas and Mandel, 2005) to repress its target genes, negatively regulates BDNF gene expression by binding to NRSE/RE1 element in BDNF promoter II (Palm et al., 1998; Timmusk et al., 1999; Bruce et al., 2004; Ballas et al., 2005).”