Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

By T. Cheutin, Adrian J. McNairn, T. Jenuwein, D. Gilbert, Prim B. Singh, Tom Misteli. Science, 2003

652 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6c5c0ac3ec7c2b10a84075e401a1abcfb2861e75

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Stochasticity in gene expression: from theories to phenotypes (2005, background): “Because heterochromatin might be better viewed as a dynamic rather than a static structur”
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. (2005, background): “HP1 binding to “heterochromatin domains” is not static but highly dynamic (Cheutin et al. 2003; Festenstein et al. 2003).”
Binary switches and modification cassettes in histone biology and beyond (2003, background): “Such a kinetically controlled binding mechanism of effector modules is sustained by the recent demonstration that binding proteins of heterochromatic methyl marks have a fast exchange rate with their environment and are not statically bound to their target site”
Beyond the sequence: cellular organization of genome function. (2007, neutral): “In both S. cerevisiae andmammaliancells, heterochromatin proteins can readily diffuse into and bind to their sites in highly condensed heterochromatin (Cheutin et al., 2003, 2004; Fes-tenstein et al., 2003).”
HP1 and the dynamics of heterochromatin maintenance (2004, result): “In contrast to this static view, experiments that were carried out using live-cell imaging and fluorescence recovery after photobleaching (FRAP) show that HP1 is not stably bound to pericentric heterochromatin, but is highly mobile and forms a stable compartment that is actively renewe”
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. (2003, background): “Indeed, recently a biochemical pathway of gene repression by heterochromatin assembly, involving methylation of Lys 9 of H3 by SET-type histone methyltransferases (HMTs), and the read-out of this methylation mark by the chromodomain of HP1 (heterochromatin protein 1), has been established (Schotta e”
Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. (2006, methodology): “Photobleaching and quantitation was performed as described (Cheutin et al., 2003; Lever et al., 2000; Phair et al., 2004).”
From silencing to gene expression: real-time analysis in single cells. (2004, background): “…the kinetics of its production HP1 to be a dynamic component of heterochromatin may provide insight not only into transcriptional regula(Cheutin et al., 2003; Festenstein et al., 2003) in contrast tion but possibly also into chromatin structure. to the core histones, which show little…”
DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. (2005, neutral): “This recovery time is comparable to that of linker istone H1 (Lever et al., 2000) but is almost ten times lower than other structural nonhistone chromatin proeins, for example HP1 (Cheutin et al., 2003, 2004; chmiedeberg et al., 2004).”