DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

By R. Klose, Shireen A. Sarraf, L. Schmiedeberg, Suzanne M. McDermott, I. Stancheva, A. Bird. 2005

378 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Dirk Schübeler
2. Jussi Taipale
3. Paul Adrian Ginno

In Molecular Biology

1. Brian D. Strahl
2. Dirk Schübeler
3. Jussi Taipale
4. Paul Adrian Ginno
5. Scott B. Rothbart
6. C. D. Allis
7. Yi Zhang
8. P. Beachy

Citations in the corpus

• Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, methodology): “The assay was performed with unmethylated DNA ligands and DNA ligands that were methylated (24) using the CpG-specific cytosine 5-methylase M.”
• Interpreting thelanguage of histone and DNA modifications (2014, background): “Differing sequence preferences have also been documented for several MBD proteins [220,221], a property to consider when using these domains as methylated CpG affinity enrichment tools.”
• The story of Rett syndrome: from clinic to neurobiology. (2007, neutral): “The MBD specifi-cally binds to methylated CpG dinucleotides, with preference for CpG sequences with adjacent A/T-rich motifs (Klose et al., 2005).”