Binary switches and modification cassettes in histone biology and beyond

By W. Fischle, Yanming Wang, C. D. Allis. Nature, 2003

658 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a401c6468709e0b68fcb2afca2c07d8cec1b2433

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Citations in the corpus

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. (2004, background): “Of the five lysine positions in the histone N termini that display prominent methylation (Peters et al. 2003), H3-K9, H3-K27, and H4-K20 are supposed to have repressive functions (Fischle et al. 2003; Lachner et al. 2003; Vaquero et al. 2003).”
DNA methylation and human disease (2005, background): “By contrast, the other main group of epigenetic modifications — the post-translational modification of histones — shows a high level of diversity and complexit”
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all (2006, background): “An obvious appeal of this idea is that the so-called 'methyl-phos switch' provides a binary mechanism for switching gene expression off and o”
Histone Deacetylase Inhibitors: Overview and Perspectives (2007, background): “It has been proposed that histone modifications, acting alone, sequentially, or in combination, represent a ‘‘code’’ that can be recognized by nonhistone proteins, which form complexes that are important for regulation of gene transcription (35).”
Epigenetics in human disease and prospects for epigenetic therapy (2004, background): “Because lysine methylation can be monomeric, dimeric or trimeric, and histones may also be subject to other post-translational modifications such as phosphorylatio”
Reconstruction of cellular signalling networks and analysis of their properties (2005, methodology): “Extensive and varied modifications of histone proteins might be a general method of regulating gene expressio”
Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm (2005, neutral): “(1) in which all the dipole–dipole couplings and chemical shielding parameters are varied.”
Vernalization requires epigenetic silencing of FLC by histone methylation (2004, background): “Pc-G proteins act in multiprotein complexes to maintain a silenced chromatin state by modifying specific amino acids in the amino-terminal tails of histones through deacetylation or methylatio”
FAK phosphorylation sites mapped by mass spectrometry (2005, background): “A similar phenomenon is known to exist in histones, where proteins that recognize methylated lysine residues are blocked by phosphorylation of adjacent serine or threonine residues ( Fischle et al., 2003 ).”
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “For example, phosphate-mediated 'phospho-methyl switching' has been proposed and shown experimentally to control the release of more stably bound chromatin effectors, such as HP1 bound to H3K9me during mitosis and probably additional effectors bound during other cell-cycle and developmentally regula”