A skin microRNA promotes differentiation by repressing ‘stemness’

By R. Yi, Matthew N. Poy, M. Stoffel, Elaine Fuchs. Nature, 2008

810 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b1e9bca63644bb9ff6c64a13fe28c894b947478

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Citations in the corpus

microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7 (2010, positive): “miR-1 and miR-206 restrict satellite cell proliferation in vivo To investigate whether miR-1 and miR-206 also restrict the proliferative potential of satellite cells in vivo, we knocked down both miR-1 and miR-206 in the skeletal muscle of neonatal mice using miRNA antagomirs (Krutzfeldt et al., 200”
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs (2009, background): “Accordingly, reduced expression of such stemness-inhibiting miRNAs can maintain a stem cell phenotyp”
Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “miRNAs seem to function in the fine-tuning of the signalling transcription factor circuitry, which prompts a basal epidermal SC to terminally differentiat”
MicroRNAs: key regulators of stem cells (2009, background): “pl?acc=MI0000283">miR-203 was found to promote skin differentiation by limiting the proliferative capacity of the skin stem cells and induce cell cycle exi”
Epithelialization in Wound Healing: A Comprehensive Review (2014, background): “miR-203, a very abundant miRNA that targets p63 and contributes to barrier formation, was recently associated with wound healing.(89,90) miR-203 is downregulated at the migrating epithelium of acute wound edges allowing the expression of p63, RAN (member of the G-protein superfamily), and RAPH1 (lam”
Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “with Normal Stem Cells”
MicroRNA control of signal transduction (2010, background): “Remarkably, however, inhibition of miRNA biogenesis (for example, through the ablation of Dicer) clearly reveals that miRNAs are essential for a wide array of biological processes, including control of proliferative homeostasis, differentiation or embryonic stemnes”
MicroRNAs in development and disease. (2011, background): “miR-203 is upregulated in differentiating keratinocytes (348, 691) and is, thus, enriched in the suprabasal epithelial cells and in differentiated epidermal cells, while being absent in the proliferating basal layer in both mouse (348) and human (657) skin.”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “In mouse epithelial cells, miRNA-203 functions as a key switch between cell proliferation and differentiation [17].”
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. (2009, positive): “Recent reports showed that differentiation of somatic stem cells (Yi et al., 2008) and mouse ESCs (Tay et al.”