Differential roles of microglia and monocytes in the inflamed central nervous system

By R. Yamasaki, Haiyan Lu, O. Butovsky, N. Ohno, A. Rietsch, R. Cialic, Pauline M. Wu, Camille E. Doykan, Jessica Lin, A. Cotleur and 15 more. Journal of Experimental Medicine, 2014

771 citations recorded by the source corpus.

Phagocytic monocyte-derived macrophages associate with the nodes of Ranvier and initiate demyelination while microglia clear debris and display a suppressed metabolic gene signature in EAE.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/692b642e51cfea9cd29e6b9fd0f5b5d4fd4ad704

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Steffen Jung
2. A. Mildner
3. C. Varol
4. M. Guilliams
5. S. Gordon
6. G. Harry
7. C. McPherson
8. Rubén Orihuela

In Neurology

1. Hans Lassmann
2. Wolfgang Brück
3. Steffen Jung
4. S. Gordon
5. Marco Prinz
6. O. Maier
7. G. Harry
8. Roman Fischer

Citations in the corpus

• Microglial M1/M2 polarization and metabolic states (2016, background): “This then brings an entirely different dynamics to the environment as compared with a response limited to resident microglia (Jung and Schwartz, 2012; Yamasaki et al., 2014).”
• Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF (2015, background): “Indeed, it has been shown that in acute EAE microglia are relatively quiescent whereas infiltrating macrophages mediate inflammation and phagocytosis [19].”
• Developmental and Functional Heterogeneity of Monocytes. (2018, result): “It was also shown that in contrast to infiltrated monocytes, microglia did not show an overt pro-inflammatory gene signature during EAE (Yamasaki et al., 2014).”
• Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “For instance, infiltrating macrophages are highly phagocytic and inflammatory, whereas native microglia appear to preferentially clear debris (Yamasaki et al., 2014).”
• Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “Early staining observations suggested that ramified macrophage-like cells, named microglia by Pio del Rio Hortega in the 1920s, performed phagocytic housekeeping functions in normal and diseased brain (30, 104, 105).”
• High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (2018, neutral): “Ly6Chi monocytes invade the CNS parenchyma and differentiate into inflammatory and pathogenic MdCs during EAE (Codarri et al., 2013; Croxford et al., 2015a, 2015b; Yamasaki et al., 2014).”
• A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, neutral): “Some reports show that under such conditions, microglia acquire pro-inflammatory activity, which has been associated with disease escalation (Heppner et al., 2015; Tejera and Heneka, 2016; Wang et al., 2015; Yamasaki et al., 2014).”
• An updated histological classification system for multiple sclerosis lesions (2016, background): “Currently, there is no antibody readily and commercially available that allows the differentiation between blood-derived monocytes and local microglial cells in tissue sections, although surface markers have been identified that can distinguish these two cell populations if isolated from the CNS and”