Mitochondria: Dynamic Organelles in Disease, Aging, and Development

By D. C. Chan. Cell, 2006

2,002 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/67bd8bec2d703e8c83920ba8ec239aee88302dad

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Citations in the corpus

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. (2006, background): “Neurons appear particularly vulnerable to mitochondrial dysfunction, as testified by the many neurodegenerative diseases, including Alzheimer’s and Huntington’s diseases, which have been associated with abnormal mitochondrial activity and dynamics (Chan, 2006).”
Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. (2008, positive): “Given that defective trafficking of axonal mitochondria is implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer’s and Huntington’s (Chan, 2006), these studies will shed light on fundamental 144 Cell 132, 137–148, January 11, 2008 ª2008 Elsevier Inc. neuronal processes that ”
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins (2008, background): “Impairments in mitochondrial dynamics are being increasingly implicated in neurodegenerative diseases (16).”
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex (2010, background): “In addition to constant movement, mitochondria also undergo frequent fission and fusion events (Chan, 2006).”
Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses (2009, positive): “…mitochon- drial dynamics compromise synaptic function and plasticity (Li et al., 2004; Verstreken et al., 2005), and defective mitochondrial trafficking is implicated in neurological and neurodegenerative disease (Alexander et al., 2000; Baloh et al., 2007; Chan, 2006; Chen and Chan, 2006).”
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “The processes of ﬁssion/fusion are controlled by GTPases, most of which were identiﬁed in genetic screens in yeast (for recent reviews see reference 4,5 ).”
Whole cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution (2008, neutral): “The distinctive morphologies likely indicate cells in different growth stages as has been demonstrated previousl”
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. (2007, background): “Current Opinion in Neurobiology 2007, 17:331–337 death [41].”
Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum (2007, positive): “Our observation that cerebellar Purkinje cells require Mfn2 directly supports emerging evidence that neurons are particularly sensitive to perturbations in mitochondrial dynamics (Chan, 2006; Chen and Chan, 2006).”
Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling (2008, background): “Mitochondria divide, fuse and move around cells [18–20], processes whose relevance is underscored by the observation that mutations in the cognate proteins can lead to disease, in particular neuronal dysfunction [19].”