Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation.

By Jian-Sheng Kang, Jin-hua Tian, Ping-Yue Pan, P. Zald, Cuiling Li, Chuxia Deng, Zu-Hang Sheng. Cell, 2008

603 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/70d2112a1d048f82046e03bc2b079b2167b20dfe

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Citations in the corpus

AXONAL TRANSPORT: CARGO-SPECIFIC MECHANISMS OF MOTILITY AND REGULATION (2014, background): “effect observed on the motility of dendritic mitochondria (Kang et al., 2008).”
The Mechanism of Kinesin Regulation by Ca++ for Control of Mitochondrial Motility (2009, positive): “Several intracellular signals have been shown to control the movement of mitochondria and thereby influence mitochondrial distribution (Boldogh and Pon, 2007; Chada and Hollenbeck, 2003, 2004; Kang et al., 2008).”
Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses (2009, positive): “Thus, Miro1 is a key determinant of how energy supply is matched to energy usage in neurons.”
The axonal transport of mitochondria (2005, background): “Syntaphilin is transported along the axon together with mitochondria; it can bind microtubules and it associates strongly with stationary but not motile mitochondria (Kang et al., 2008).”
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model (2010, background): “Defects in synaptic mitochondria obviously compromise synaptic function (1, 6, 7), and synaptic mitochondria are vulnerable to accumulative damages.”
Mitochondria: In Sickness and in Health (2012, background): “Physical tethers are also thought to be important to stably position mitochondria at specific locations within cells, for example, in the axons and dendrites of neurons or in muscle fibers for efficient energy utilization (Garcı́a-Pérez et al., 2011; Kang et al., 2008).”
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex (2010, background): “Mitochondrial transport is regulated by a series of molecular adaptors that mediate the attachment of mitochondria to molecular motors (Hollenbeck and Saxton, 2005; Kang et al., 2008; Li et al., 2009).”
Metabolic regulation of mitochondrial dynamics (2016, background): “In the third, most recent model, mitochondrial pausing in axons is mediated by the protein syntaphilin, which serves to anchor axonal mitochondria to microtubules (Kang et al., 2008; Chen and Sheng, 2013).”