Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

By E. Zeisberg, O. Tarnavski, M. Zeisberg, A. Dorfman, J. McMullen, E. Gustafsson, A. Chandraker, Xueli Yuan, W. Pu, A. Roberts and 4 more. Nature Medicine, 2007

2,217 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/e5b209b18422d2529f8ecc7302cbcd52bc5b58b5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Nikolaos G. Frangogiannis
2. M. Nieto
3. J. López-Novoa
4. Joseph A. Hill
5. A. Takawale
6. TA Wynn
7. Z. Kassiri

In Molecular Biology

1. M. Nieto
2. Raghu Kalluri
3. Nikolaos G. Frangogiannis
4. Jeremy S. Duffield
5. R. Weinberg
6. Zena Werb
7. J. P. Thiery
8. TA Wynn

In Surgery

1. Nikolaos G. Frangogiannis
2. M. Nieto
3. TA Wynn
4. J. López-Novoa
5. J. P. Thiery
6. Raghu Kalluri
7. H. Acloque
8. M. Zeisberg

Citations in the corpus

• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “, 2003), and cytokines such as bone morphogenetic protein-7 (BMP7) have been shown to play a role in this reversal in several organs and tissues, including transdifferentiated MCs (Zeisberg et al., 2003; Zeisberg et al., 2007; Vargha et al., 2006).”
• Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle (2011, background): “In addition, Zeisberg et al. reported that adult hepatocytes contribute to liver fibrosis by means of an epithelial–mesenchymal transition (EMT) (Zeisberg et al., 2007b).”
• Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, background): “A similar process also occurs when endothelial cells undergo an EMT during cardiac or renal fibrosis (EndMT; Zeisberg et al, 2007b, 2008) as well as during mesothelial fibrosis in patients subjected to peritoneal dialysis where the NF-kB/Snail1 axis has already been described (Strippoli et al,…”
• The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, methodology): “The TGFβ pathway has also been a target for inhibition using similar strategies as well as treatment with bone morphogenetic protein 7, an endogenous inhibitor of TGF-β signaling, particularly for the treatment of fibrosis (Zeisberg et al. 2003).”
• Methylation determines fibroblast activation and fibrogenesis in the kidney (2010, neutral): “We used Alexa488- and Alexa595-labeled secondary antibodies (Invitrogen”
• Epithelial-mesenchymal transitions in development and disease. (2009, background): “EMT involving transformation of endothelial cells into mesenchymal cells is evident during cardiac and renal fibrosis (EndMT) (Zeisberg et al., 2007a, 2008).”
• Cellular and molecular mechanisms of fibrosis (2008, background): “In addition to resident mesenchymal cells, myofibroblasts are derived from epithelial cells in a process termed epithelial–mesenchymal transition (EMT) [10–12].”