Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
By Tongyan Liu, Chencheng Han, Siwei Wang, Panqi Fang, Zhifei Ma, Lin Xu, R. Yin. Journal of Hematology & Oncology, 2019
754 citations recorded by the source corpus.
Among all the stromal cells that present in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor mesenchyme, which not only provide physical support for tumor cells but also play a key role in promoting and retarding tumorigenesis in a context-dependent manner. CAFs have also been involved in the modulation of many components of the immune system, and recent studies have revealed their roles in immune evasion and poor responses to cancer immunotherapy. In this review, we describe our current understanding of the tumorigenic significance, origin, and heterogeneity of CAFs, as well as the roles of different CAFs subtypes in distinct immune cell types. More importantly, we highlight potential therapeutic strategies that target CAFs to unleash the immune system against the tumor.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/c11c399ae2e093e4807908fd9684e2f07e1e2f2b
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Citations in the corpus
- Tumor microenvironment complexity and therapeutic implications at a glance (2020, background): “CAFs produce ECM proteins, which prompts immunosuppression of tumor cells by recruiting immunosuppressive cells [64, 65] such as monocytes and inducing immunosuppressive PD-1+ TAMs, as recently shown in breast cancer cells in vitro [66] .”
- Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “Generally, CAFs are derived from the activated local tissueresident fibroblasts, fibrocytes recruited from bone marrow, mesenchymal stem cells (MSCs) and stellate cells, or are the products of the mesenchymal transition of epithelial and endothelial cells, and the transdifferentiation of pericytes, ”