Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

By Steffen Jung, J. Aliberti, Petra Graemmel, M. Sunshine, G. Kreutzberg, A. Sher, Dan R. Littman. Molecular and Cellular Biology, 2000

2,537 citations recorded by the source corpus.

Subfields: Genetics, Insect Science, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/6701dd43b7c1ff8f51e5612cc4223a4f86d4cee1

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In Genetics

1. U. Hanisch
2. Dan R. Littman
3. Steffen Jung
4. V. Brinkmann
5. N. Mackman

Citations in the corpus

• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “In contrast, Cx3cr1 deficiency was protective in a focal cerebral ischemia model with smaller infarcts and reduced inflammation (Denes et al., 2008) and in a mouse model of Alzheimer’s disease (Fuhrmann et al., 2010) where neuronal loss was prevented.”
• Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, methodology): “To further characterize the composition of the lpDC compartment of the small and large intestine, we took advantage of Cx3cr1 mice, in which one allele of the gene encoding the CX3CR1 chemokine receptor has been replaced with a green fluorescent protein gene (gfp) (Jung et al., 2000).”
• Blood monocytes consist of two principal subsets with distinct migratory properties. (2003, background): “In light of their apparently different physiologiAnimals cal functions, defects in one or the other subset may CX3CR1 mice were generated in the laboratory (Jung et al., 2000) therefore result in different types of diseases.”
• Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages (2012, methodology): “1+ mice, Cx3cr1gfp/+C57BL/6 mice (Jung et al., 2000), and Csf1rgfp/+C57BL/6 mice (Macrophage Fas-induced apoptosis, MaFIA; Burnett et al., 2004) were purchased from the The Jackson Laboratory.”
• Differential roles of microglia and monocytes in the inflamed central nervous system (2014, neutral): “Ccr2 rfp/+ :: Cx3cr1 gfp/+ mice were generated by crossbreeding Ccr2 rfp/rfp ::C57BL/6 mice (Saederup et al., 2010) with Cx3cr1 gfp/gfp ::C57BL/6 mice ( Jung et al., 2000).”
• The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “This expression profile of CX3CR1 has been confirmed conclusively by the development of a transgenic mouse in which the CX3CR1 contains a green fluorescent protein reporter allowing visualisation of the transcribed protein; here, in the mouse, CX3CR1 protein was observed in microglia throughout the ”
• Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice (2009, neutral): “chemokine receptor alleles is replaced with a gene encoding GFP [green fluorescent protein]”