Blood monocytes consist of two principal subsets with distinct migratory properties.

By F. Geissmann, Steffen Jung, Dan R. Littman. Immunity, 2003

3,609 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/3cf100f9958337f12575ab261a96900ad737270f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Peter Libby
2. A. Mantovani
3. Steffen Jung
4. R. Ransohoff
5. A. Mildner
6. J. Pollard
7. Eric G. Pamer
8. M. Guilliams

In Oncology

1. J. Pollard
2. Peter Libby
3. Zena Werb
4. Eric G. Pamer
5. M. Pittet
6. F. Geissmann
7. Andrew J. Ewald
8. M. Egeblad

Citations in the corpus

• Monocyte recruitment during infection and inflammation (2011, background): “Monocyte subsets and chemokine receptors Monocytes are divided into subsets on the basis of chemokine receptor expression and the presence of specific surface molecule”
• Use of Ly6G‐specific monoclonal antibody to deplete neutrophils in mice (2008, background): “As reported by others, 1A8 (anti-Ly6G) identified blood neutrophils but not blood monocytes or blood lymphocytes [12]; RB6-8C5 (anti-Gr-1) identified blood neutrophils and a subpopulation of blood monocytes [18, 19].”
• Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia (2013, positive): “…in order to determine whether there was similar expression of these genes in human microglia, we performed qPCR in both fetal and adult human CNS-derived microglia and human blood-derived CD14 + CD16 − and CD14 + CD16 + monocytes which are analogous to murine Ly6C Hi and Ly6C Low subsets 13 .”
• The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages (2010, background): “Macrophage heterogeneity is influenced by differentiation state, with marked differences between monocytes and macrophages [1,40].”
• The chemokine system in innate immunity. (2015, neutral): “1) (Geissmann et al. 2003).”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “Based on our FACS data, the fast migratory cfms+/Gr1+ cell population in the tumor stroma probably consists of granulocytes, MDSCs or monocytes (Geissmann et al., 2003).”
• Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response1 (2004, background): “monocytes indicated that CX3CR1 low (our Ly-6C) monocytes correspond to the classical CD14CD16 monocytes, whereas CX3CR1 high (our Ly-6C ) monocytes resemble CD14CD16 cells (14).”
• Immune cell migration in inflammation: present and future therapeutic targets (2005, background): “Macrophage subsets are less well defined than T cell subsets, although studies have identified a CCR2 hi CX3CR1 lo inflammatory subset and a CCR2 lo CX3CR1 hi homeostatic subse”
• AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity1 (2009, background): “Monocytes have the capacity to differentiate into DCs (27, 30) and such a differentiated population can be detected by the expression of the cell surface markers Ly6C, CD11b, and F4/80 (31, 32).”