The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

By M. Johansson, J. Larsson, G. Hansson. Proceedings of the National Academy of Sciences of the United States of America, 2010

1,386 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1c4370eb6e003314c6d32ee644c1e7ce1a7c713c

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Citations in the corpus

Pathological bacterial translocation in liver cirrhosis. (2014, background): “In contrast, the ‘‘loose’’ outer layer is the habitat for commensal bacteria that consume the mucus proteins as a carbon source [60] and provides specific binding sites for bacterial adhesins [61].”
Mucin glycan foraging in the human gut microbiome (2015, background): “In the colon, the mucus is divided into an outer layer which provides a nutrient-rich habitat for the microbiota and an inner layer firmly attached to the surface of the epithelium, and virtually free of bacteria (Johansson et al., 2008, 2011).”
The composition of the gut microbiota shapes the colon mucus barrier (2014, neutral): “The commensal bacteria live in the non-attached and expanded outer mucus of colon [26], where they can cleave off and utilize mucin glycans as energy source.”
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals (2019, background): “Furthermore, after entering the cell membrane, cellular components such as enzymes may degrade/decompose the drug molecules in the cytosol, decreasing the therapeutic efficiency [89].”
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity (2013, background): “J Clin Endocrinol Metab 96(9):E1409–E1417.”
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. (2014, background): “Taken together, these results highlight both mutualistic and syntrophic interactions between bacteria that play a role in the coaggregation of taxa residing together in a spatially defined architecture such as have been described for biofilms.(39,52) Such interactions recently have been suggested by”
Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces (2013, background): “SIgA anchoring in mucus may account for the observation that the outer mucus layer is the preferential habitat for the microbiota in the colon (75).”