The axonal transport of mitochondria

By W. Saxton, P. Hollenbeck. Journal of Cell Science, 2005

996 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/65077f1f8ad4891721a27fe67d667f0cd5504ac0

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Citations in the corpus

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex (2010, background): “Mitochondrial transport is regulated by a series of molecular adaptors that mediate the attachment of mitochondria to molecular motors (Hollenbeck and Saxton, 2005; Kang et al., 2008; Li et al., 2009).”
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration (2012, background): “Owing to their unique metabolic requirements, these areas do not display a uniform mitochondrial distribution (reviewed in Ref”
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “Likewise, normal mitochondrial dynamics is important for maintaining polarity in highly polarized neurons [3].”
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. (2010, positive): “Besides, it has long been known that the localization of mitochondria is controlled by Ca 2+ signaling (Hollenbeck and Saxton, 2005).”
Mitochondrial dynamics regulates migration and invasion of breast cancer cells (2012, background): “Indeed, mitochondrial fission directs mitochondria to concentrate in neuronal areas that are expected to have higher ATP consumption and is critical for neurite growth (14).”
AXONAL TRANSPORT: CARGO-SPECIFIC MECHANISMS OF MOTILITY AND REGULATION (2014, background): “In axons of hippocampal neurons grown in vitro, 20%–30% of mitochondria are motile, moving equally in both anterograde and retrograde directions; the remaining 70%–80% are stationary (reviewed in Hollenbeck and Saxton, 2005).”
Metabolic regulation of mitochondrial dynamics (2016, background): “…mammalian cells, mitochondrial transport is accomplished via the activity of motor proteins working along the microtubule network, although transport along other metabolic regulation of mitochondrial dynamics • mishra and Chan 383 cytoskeletal elements can also occur (Saxton and Hollenbeck, 2012).”
Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines (2010, background): “As shown previously (Stamer et al., 2002; Hollenbeck and Saxton, 2005; Thies and Mandelkow, 2007), such mitochondrial traffic jams cause a local drop of energy (ATP) and consequently spine destruction through the perturbation of the actin network and loss of synaptic components (Whiteman et al.,…”
Mitochondria: In Sickness and in Health (2012, background): “Miro (blue feet) is a mitochondrial receptor for kinesin viaMilton that facilitates the transport of mitochondria on microtubules in a Ca2+-regulated manner.”