Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.

By N. Hirokawa, Shinsuke Niwa, Yosuke Tanaka. Neuron, 2010

1,102 citations recorded by the source corpus.

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as synaptic vesicle precursors, neurotransmitter and neurotrophic factor receptors, and mRNAs within axons, dendrites, and synapses. Recent studies have begun to clarify the mechanisms of cargo selection and directional transport in subcellular compartments. Furthermore, molecular genetics has revealed unexpected roles for molecular motors in brain wiring, neuronal survival, neuronal plasticity, higher brain function, and control of central nervous system and peripheral nervous system development. Finally, it is also evident that molecular motors are critically involved in neuronal disease pathogenesis. Thus, molecular motor research is becoming an exciting frontier of neuroscience.

Subfields: Cell Biology, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/05d5bf63de1c186cfc13522d625ce6d384a5efdf

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Citations in the corpus

• Neurofilaments and Neurofilament Proteins in Health and Disease (2017, background): “Membranous organelles are the main constituents of the fast transport component, and although the molecular mechanisms underlying their transport have become increasingly clear (Hirokawa et al. 2010; Zala et al. 2013), those regulating the slow transport of cytoskeletal and associated proteins have ”
• AXONAL TRANSPORT: CARGO-SPECIFIC MECHANISMS OF MOTILITY AND REGULATION (2014, background): “Thus, continued research into the molecular mechanisms involved in axonal transport and its regulation should provide 302 Neuron 84, October 22, 2014 ª2014 Elsevier Inc. new insights pointing toward development of novel therapeutic approaches in the future.”
• Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “ 628]. Movement of the cargo in a direction away from the cell body is called anterograde whereas that in the reverse direction is called retrograde; therefore, both kinesins and dyneins are involved [630, 631, 632]. Every cargo in an axon spends a fraction of its journey time actually moving and ev”
• Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration (2012, background): “They drive long-distance transport of mitochondria and other membranous organelles or cargoes through mechanisms that require ATP hydrolysis (reviewed in Ref”