Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.

By G. Cheng, Z. Cao, X. Xu, Erwin G. Van Meir, J. Lambeth. Gene, 2001

841 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/64b0f39469d9874a1b86ae9e4f3596a4d51103ad

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. K. Griendling
2. S. Chakraborty
3. Kuldeep Dhama

In Immunology

1. K. Griendling
2. B. Lassègue
3. R. Clempus
4. David I. Brown
5. R. Stocker
6. K. Krause
7. H. Forman
8. F. Ursini

In Physiology

1. K. Griendling
2. B. Lassègue
3. R. Clempus
4. David I. Brown
5. K. Krause
6. H. Forman
7. K. Bedard
8. J. Keaney

Citations in the corpus

• Nox proteins in signal transduction (2009, positive): “Indeed, it has been detected in fetal spleen, kidney, lung and skull by PCR [13,18], which may indicate that Nox3 plays an important role in tissue development, but is turned off in adult tissue, a concept that requires further investigation.”
• Reactive oxygen species in vascular biology: implications in hypertension (2004, neutral): “Recent studies demonstrated that the newly discovered gp91phox (Nox2) homologs, Nox1, Nox4, and Nox5 (Nox for NAD(P)H Oxidase) are found in the vasculature (Suh et al. 1999; Cheng et al. 2001; Ago et al. 2004; Hilenski et al. 2004).”
• NADPH Oxidases in Cardiovascular Health and Disease (2006, neutral): “Finally, the expression of Rac isoforms also among different cell types with Rac2 being the main isoform found in phagocytes, whereas Rac1 is the predominant isoform in most nonphagocytic cells.”
• The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. (2007, background): “Sequence alignment and hydropathy plot analysis predict the overall structure of NOX3 to be highly similar to that of NOX1 and NOX2, in terms of transmembrane domains, the length of the extracellular loops, NADPH- and FAD-binding sites, and the localization of the heme-coordinating histidines (143, ”
• Role of oxidative modifications in atherosclerosis. (2004, background): “in vascular cells (147, 864), with endothelial cells express-”
• Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, background): “Furthermore, it was also discovered that the catalytic subunit gp91phox is only one member of a new family of homologous proteins termed nox (for NADPH oxidase) (11, 101, 102, 186) and that most cells express multiple nox proteins (30).”
• Oxidative Stress, Prooxidants, and Antioxidants: The Interplay (2014, background): “Other sources of ROS may be reactions involving peroxisomal oxidases [94], cytochrome P-450 enzymes [95], NAD (P)H oxidases [96], or xanthine oxidase [97].”
• Signaling Functions of Reactive Oxygen Species (2010, background): “Although NF-κB activation in stimulatedmacrophages by endogenously generated H2O2 was then demonstrated (13), it was not until the existence NADPHoxidases of nonphagocytic cells was discovered (14-16) that physiological signaling by reactive oxygen species became a major topic of interest.”