Nox proteins in signal transduction

By David I. Brown, K. Griendling. Free Radical Biology & Medicine, 2009

833 citations recorded by the source corpus.

The NADPH oxidase (Nox) family of superoxide (O2•−) and hydrogen peroxide (H2O2) producing proteins has emerged as an important source of reactive oxygen species (ROS) in signal transduction. ROS produced by Nox proteins Nox1-5 and Duox1/2 are now recognized to play essential roles in the physiology of the brain, the immune system, the vasculature, the digestive tract, and hormone synthesis. Nox-derived ROS have been implicated in regulation of cytoskeletal remodeling, gene expression, proliferation, differentiation, migration and cell death. These processes are tightly controlled and reversible. In this review, we will discuss recent literature on Nox protein tissue distribution, subcellular localization, activation and the resulting signal transduction mechanisms.

Subfields: Immunology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/305f92389f6ffd12efceef8507e14dc94bb784ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Dikalov
2. K. Griendling
3. P. Chiarugi
4. E. Giannoni
5. Navdeep S. Chandel
6. C. Iadecola
7. Rhian M. Touyz
8. E. Schiffrin

In Neurology

1. S. Dikalov
2. S. Gandhi
3. A. Abramov
4. K. Griendling
5. Navdeep S. Chandel
6. Rui‐Ming Liu
7. L. Desai

In Physiology

1. S. Dikalov
2. Lucas B. Sullivan
3. S. Gandhi
4. A. Abramov
5. K. Griendling
6. Navdeep S. Chandel
7. C. Iadecola
8. Rhian M. Touyz

Citations in the corpus

• Mitochondrial reactive oxygen species and cancer (2014, background): “Since this discovery, it has been observed that NADPH oxidase family members are present in many tissues in the body where they are important for non-immune functions as well [10,11].”
• ROS and ROS-Mediated Cellular Signaling (2016, background): “NADPH oxidases (Nox) including Nox1 to Nox5 and Duox1 and Duox2, which are classified into three groups, according to the presence of domains in addition to the gp91phox (NOX2) domain, are another important source of cellular ROS [17, 18]: NOX1, NOX3, and NOX4 are similar in size and domain structur”
• Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets (2011, background): “ROS may also oxidize matrix metalloproteinases , leading to their activation and the subsequent promotion of vascular remodellin”
• Anoikis molecular pathways and its role in cancer progression. (2013, background): “creases Nox expression, contributing to maintain high levels of ROS production [33].”
• The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function (2011, neutral): “NOX-catalysed ROS production occurs to high levels in phagocytic cells as a host defence mechanism and at lower levels in other cell types to facilitate mitogenesis and motilit”
• Mechanism of Oxidative Stress in Neurodegeneration (2012, background): “The physiological role of NOX enzymes in brain cells is still unclear and described mostly as an effect of superoxide produced by NADPH oxidase [87].”
• Crosstalk between mitochondria and NADPH oxidases (2011, background): “Originally isolated from the thyroid, they produce the H2O2 that is used to oxidize iodide during thyroid hormone synthesis [94].”