Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.

By Rongze Yang, Mi-Jeong Lee, Hong Hu, Jessica Pray, Hai-bin Wu, B. Hansen, A. Shuldiner, S. Fried, J. Mclenithan, D. Gong. American Journal of Physiology. Endocrinology and Metabolism, 2006

902 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/6443752261acf6f0003d5961da6bcc2e4898b788

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Chait
2. Laura J. den Hartigh
3. M. Trujillo
4. A. Benito-Vicente
5. A. Larrea-Sebal
6. U. Galicia-Garcia
7. P. Calder
8. P. Scherer

In Molecular Biology

1. M. Trujillo
2. P. Calder
3. P. Scherer
4. H. Kwon
5. J. Pessin
6. A. Chait
7. Laura J. den Hartigh
8. I. Graham

In Physiology

1. M. Trujillo
2. A. Chait
3. Laura J. den Hartigh
4. P. Calder
5. P. Scherer
6. S. Fried
7. H. Kwon
8. J. Pessin

Citations in the corpus

• Adipokines: the missing link between insulin resistance and obesity. (2008, background): “Interestingly, it increases insulin-stimulated lucose uptake in both omental and subcutaneous adipocytes, nd promotes Akt phosphorylation [92].”
• Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “Omentin-1 enhances the insulin-induced glucose uptake in human visceral and subcutaneous adipocytes through increased phosphorylation of AKT/PKB (Yang et al., 2006).”
• Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, positive): “SAA and leptin production by adipose tissue depends on adipocyte size((18,19,23,62)).”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Initially described as an adipokine secreted from omental WAT (119), it is now generally accepted that omentin is also expressed in other WAT depots such as epicardial fat, and that it derives specifically from the stromal vascular fraction ofWAT (119, 120).”
• Pathophysiology of Type 2 Diabetes Mellitus (2020, background): “In vitro studies have shown that omentin enhances insulin-stimulated glucose uptake in human adipocytes by AKT signaling pathway activation [273].”
• Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, background): “$w aterm ark-text $w aterm ark-text $w aterm ark-text IL-6 interleukin-6 SAA serum amyloid A RBP4 retinol binding protein 4 MCP-1 macrophage chemoattractant protein-1 CRP C-reactive protein GM-CSF granulocyte-macrophage colony stimulating factor TSP-1 thrombospondin 1 References Alberti KG, Eckel RH”
• Omentin Plasma Levels and Gene Expression Are Decreased in Obesity (2007, methodology): “It is expressed in intestinal Paneth cells (17), endothelial cells (16), and visceral adipose stromal-vascular cells (11).”
• Adipose tissue-derived factors: impact on health and disease. (2006, background): “In fact, several adipose tissue-derived hormones such as resistin, omentin, and visfatin (also known as pre-B-cell colony-enhancing factor) are produced by several other tissues as well (17, 18, 80).”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “In contrast, omentin, identified in the human omental adipose depot, regulates blood glucose level by enhancing insulin action and is decreased in obesity (36, 37).”
• Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, neutral): “Omentin is a 38 kDa protein primarily expressed in omental fat and is thought to be secreted primarily from stromal vascular cells, not adipocytes, within the tissue compartment (711).”