Prefrontal neurons and the genetics of schizophrenia.

By Daniel R. Weinberger, Michael Egan, A. Bertolino, J. Callicott, Venkata S. Mattay, B. Lipska, Karen Faith Berman, Terry E. Goldberg. Biological Psychiatry, 2001

714 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/643a99bd45663d6718ff004c8ec68a62ce18243e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Psychiatry and Mental health

Citations in the corpus

Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia (2009, background): “Functional neuroimaging has revealed DLPFC dysfunction during WM tasks in patients with schizophrenia and also in their first-degree relatives (7, 9).”
Hierarchical Organization of Human Cortical Networks in Health and Schizophrenia (2008, background): “Moreover, there were numerous between-group differences in regional clustering and other properties, involving mainly components of frontal, medial temporal, cingulate, and insular cortex, many of which have been suggested previously to be anatomically abnormal in schizophrenia (Weinberger et al., 2”
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (2004, background): “The effect of the Val/Met polymorphism on dopamine-mediated frontal cortical function may be the neurobiological mechanism behind the clinical associations with CNS disorders (Weinberger et al. 2001).”
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. (2004, background): “emphasized the importance of prefrontal cortical dysfunction in schizophrenia [ 1 ].”
The endophenotype concept in psychiatry: etymology and strategic intentions. (2003, background): “The enzyme catechol O-methyltransferase (COMT), the gene for which is found at 22q11.”
A highly significant association between a COMT haplotype and schizophrenia. (2002, background): “Nonetheless, the combination of previous functional evidence presented for COMT in the context of schizophrenia (Weinberger et al. 2001) and the discoveries elaborated in the present study certainly point toward COMT as a susceptibility gene for schizophrenia.”
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “Some recent theories of schizophrenia postulate instead a hypodopaminergic state in the PFC (presumably related to negative symptoms and cognitive impairment) and a dysregulated dopaminergic state subcortically (perhaps associated with positive symptoms) (Weinberger et al, 2001).”
The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “In schizophrenia, there appears to be excessive transmission of the allele that produces more COMT activity and less PFC DA (Egan et al., 2001; Weinberger et al., 2001; Goldberg et al., 2003; Matsumoto et al., 2003).”