The endophenotype concept in psychiatry: etymology and strategic intentions.

By I. Gottesman, Todd D. Gould. American Journal of Psychiatry, 2003

5,644 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c3bfde1400e42344bf7f691af3546ca0685b1d7c

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Citations in the corpus

The cognitive neuropsychology of obsessive-compulsive disorder: A critical review (2015, neutral): “…(occurring within an individual whether or not he or she displays the disorder), co-segregation between the endophenotype and illness within families, and presence in unaffected relatives at a higher rate than in the general population (Gottesman & Gould, 2003; Gould & Gottesman, 2006).”
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (2004, background): “Biological endophenotypes related to neurological function may help identify predisposing factors that increase the vulnerability to alcohol dependence ( Gottesman and Gould 2003 ).”
The DMGT: Changes Within, Beneath, and Beyond (2013, background): “Similarly, Gottesman & Todd (2003) explain that in the case of phenomena having multi-gene origins endophenotypes provide “a means for identifying the “downstream” traits or facets of clinical phenotypes, F. Gagné 10 as well as the “upstream” consequences of genes” (p. 637).”
Neurobiology of suicidal behaviour (2003, background): “According to Gottesman and Gould (2003), an intermediate phenotype should be associated with the clinical phenotype, should predict the occurrence of problems in offspring, should be inherited, and should show evidence that it mediates the transmission of the general clinical phenotype after…”
Gene–environment interactions in psychiatry: joining forces with neuroscience (2006, background): “Endophenotypes are heritable neurophysiological, biochemical, endocrinological, neuroanatomical or neuropsychological constituents of disorder”
Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. (2008, background): “…relatives (Menzies et al., 2007) indicating that they may be a marker of genetic risk for OCD, and could potentially be useful in clarifying both the diagnostic classification of OCD and its underlying genetic basis; for review of the principles of endophenotypes see Gottesman and Gould (2003).”
A Heuristic for Developing Transdiagnostic Models of Psychopathology (2011, background): “Endophenotypes are intermediate phenotypes that are heritable (Gottesman & Gould, 2003).”
Network analysis: an integrative approach to the structure of psychopathology. (2013, background): “Of particular interest is the analysis of endophenotypes (Cannon & Keller 2006, Gottesman & Gould 2003).”
Delayed reward discounting and addictive behavior: a meta-analysis (2011, background): “An intermediate phenotype refers to any biological or behavioral characteristic that is both genetically influenced and significantly associated with risk for a disorder (Flint andMunafò 2007; Goldman and Ducci 2007; Gottesman and Gould 2003).”
Genetic foundations of human intelligence (2009, background): “2006), suggesting that these physiological brain measures may be endophenotypes (Gottesman and Gould 2003), or physiological markers of intelligence.”
Child Temperament: An Integrative Review of Concepts, Research Programs, and Measures (2008, background): “In other words, research might find that endophenotypes (Gottesman & Gould, 2003), such as attentional responses to novelty, relate to specific genes, such as those that influence availability of the neurotransmitter dopamine.”
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data (2014, positive): “The endophenotype hypothesis, long advocated by psychiatric geneticists such as Irving Gottesman (Gottesman and Gould 2003; Blangero 2004; Goldman 2012; White and Gottesman 2012; Kendler and Neale 2010) suggested that one might fruitfully apply genetic screening to any reliable and heritable…”
Genetics of the Human Personality (2010, background): “The endophenotype concept in psychiatry was comprehensively described by Gottesman & Gould (2003).”
Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “This classic approach to establishing endophenotypes (Gottesman and Gould, 2003) was recently implemented in a study by Ersche et al. (2010) that examined impulsivity and sensation seeking in a large group of stimulant abusers and their siblings, as well as age-and IQ-matched controls.”