A highly significant association between a COMT haplotype and schizophrenia.
By S. Shifman, Michal Bronstein, M. Sternfeld, Anne Pisanté-Shalom, E. Lev-Lehman, Abraham Weizman, I. Reznik, B. Spivak, N. Grisaru, L. Karp and 11 more. American Journal of Human Genetics, 2002
738 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/02e5cbf7400efd0f248ab54d94e6e77629b24ecb
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Citations in the corpus
- Genetic basis for individual variations in pain perception and the development of a chronic pain condition. (2005, methodology): “LD analysis of the COMT SNPs (18,19,28) and with the report of Gabriel et al.”
- The genetics of addictions: uncovering the genes (2005, background): “cgi?id=181500">schizophrenia was more robust than the Val158 allele itsel”
- Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (2004, background): “The 3′ flanking SNP near the polyadenylation site has been reported to be strongly associated with schizophrenia and to affect differential expression of Val/Met alleles (Shifman et al. 2002; Bray et al. 2003).”
- Intermediate phenotypes and genetic mechanisms of psychiatric disorders (2006, background): “A haplotype combining the Val/Met polymorphism (rs4680) with two common single nucleotide polymorphisms at other loci, one upstream in intron 1 (rs737865) and the other in a 3′ untranslated region (rs165599), was highly associated with schizophrenia in a large sample of Israelis of Ashkenazi descen”
- The genetics of schizophrenia and bipolar disorder: dissecting psychosis (2005, background): “68 73–75 However, we have been unable to find evidence for association between the single nucleotide polymorphisms (SNPs) or haplotypes that were positive in three of the studies, 68 73 75 including the Val/Met polymorphism, in a study of more than 2800 individuals, including almost 1200 with…”
- The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “…meta-analysis was a large case–control study of Ashkenazi Jews who provided strong evidence for an association of the COMT gene with schizophrenia, albeit the association was stronger for two nearby SNPs (rs737865 and rs165599) than for the Val158Met polymorphism (rs165688) (Shifman et al, 2002).”