Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

By G. Adams, Karissa T. Chabner, Ian R. Alley, D. P. Olson, Z. Szczepiorkowski, M. Poznansky, C. Kos, M. Pollak, E. Brown, D. Scadden. Nature, 2006

790 citations recorded by the source corpus.

Subfields: Hematology, Physiology

View Paper: https://www.semanticscholar.org/paper/62db921dea0b4ac5e52e2fcef19f86c0664195a4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. S. Morrison
2. Lei Ding
3. Anne Wilson
4. A. Trumpp

In Physiology

1. Kate Schroder
2. S. Morrison

Citations in the corpus

• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Osteoblasts and osteoclasts elaborate factors that regulate HSC maintenance and localization (Adams et al., 2006; Arai et al., 2004; Calvi et al., 2003; Kollet et al., 2006; Zhang et al., 2003).”
• Endothelial and perivascular cells maintain haematopoietic stem cells (2012, background): “Endothelial cells and perivascular stromal cells are probably not the only components of the HSC niche, as other cell types probably contribute through mechanisms other than SCF production (for example, ref”
• Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo1 (2008, background): “Extracellular calcium is known to be an important physiological stimulus of bone formation (28) and high extracellular calcium concentrations are a characteristic feature of the bone microenvironment (29).”
• Bone-marrow haematopoietic-stem-cell niches (2006, background): “These data indicate that local calcium gradients, as are observed around areas of bone remodelling, might be involved in engraftment and/or retention of HSCs to the endosteal nich”
• Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells (2006, background): “Notably, the calcium-sensing receptor (CaR) is essential for stem cell migration and lodgment in their endosteal niche, suggesting preferential localization of homing stem cells in close proximity to calcium-releasing OCL”