Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo1

By M. Chang, L. Raggatt, Kylie A Alexander, J. Kuliwaba, N. Fazzalari, Kate Schroder, E. Maylin, V. Ripoll, David A. Hume, A. Pettit. Journal of Immunology, 2008

706 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/07c159e7198323e7e6e7663688d9fe8416e5ca53

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In Immunology

1. Miriam Merad
2. D. Hashimoto
3. P. Frenette

In Molecular Biology

1. T. Martin
2. S. Goodman
3. Zhenyu Yao
4. N. Sims
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Citations in the corpus

• Inflammation, Fracture and Bone Repair (2016, background): “ture over osteoblasts at diaphyseal endosteal surfaces of young growing mice, and depletion of these osteomacs in macrophage fas-induced apoptosis (Mafia) transgenic mice completely suppresses this osteoblast surface and thus bonemodeling [86].”
• Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. (2014, background): “What has been shown in the mouse is that tissue-specific macrophages (‘osteomacs’) form a canopy structure over mature osteoblasts at sites of bone formation, that is, in remodeling.(12) A similar structure to the BRC has been predicted at remodeling sites in the mouse,(13) but has yet to be shown.”
• Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche (2011, methodology): “…markers of BM mononuclear phagocytes Depletion of monocytes (MO) and/or M from the BM has been accomplished with injection of clodronate liposomes (Giuliani et al., 2001) and injection of the FK-binding protein dimerizer AP20187 in transgenic Mafia mice (Burnett et al., 2004; Chang et al., 2008).”