Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2

By A. Velcich, Wancai Yang, J. Heyer, A. Fragale, C. Nicholas, S. Viani, R. Kucherlapati, M. Lipkin, Kan Yang, L. Augenlicht. Science, 2002

949 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/62baaf6d3fe1c12a166700f540fa5a146ea3ef29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. M. van de Wetering
3. Vincent W. Yang
4. Bree G. Goldstein
5. Catherine S. Lee
6. Klaus H. Kaestner
7. J. Katz
8. D. Kufe

In Molecular Biology

1. Hans Clevers
2. D. Kufe
3. M. van de Wetering
4. Vincent W. Yang
5. Bree G. Goldstein
6. Catherine S. Lee
7. Klaus H. Kaestner
8. M. Johansson

In Pathology and Forensic Medicine

1. Hans Clevers

Citations in the corpus

• Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress (2010, background): “In mice deficient in the major goblet cell mucin, Muc2 (Muc2), no morphologically identifiable goblet cells can be identified as the theca collapse, despite the continued presence of other goblet cell products, such as intestinal trefoil factor (TFF3) [7].”
• SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes (2004, background): “MUC2 deficiency also leads to spontaneous intestinal tumors (Velcich et al., 2002).”
• Mucins in cancer: protection and control of the cell surface (2004, positive): “Targeted inactivation of the murine Muc2 gene (a secreted mucin that is predominantly expressed in the small intestine and colon) resulted in a strain of mice of which 65% spontaneously developed tumours of the small intestine, colon and rectum within 1 year of birt”
• The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions (2010, background): “Depending on environmental (animal house) conditions, these mice develop more or less severe inflammation, diarrhea, colon prolapsis, and failure to thrive, and have an increased risk of developing colon cancer (16, 45, 46).”
• The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. (2002, background): “Mice deficient in Muc2, the most abundant murine intestinal mucin, display aberrant intestinal crypt morphology, with altered cell maturation and migration (Velcich et al., 2002).”
• Mucins in cancer: function, prognosis and therapy (2009, background): “Functionally, MUC2 suppresses inflammation in the intestinal tract and thereby inhibits the development of intestinal tumour”