Mucins in cancer: protection and control of the cell surface

By M. Hollingsworth, B. Swanson. Nature Reviews. Cancer, 2004

1,784 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/40a7e4975fef9eb5fa7f707e6873ccd904456f46

How researchers see this paper

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In Cell Biology

1. J. Esko

In Molecular Biology

1. L. Ensign
2. J. Hanes
3. P. Mukherjee
4. Richard D. Cummings
5. J. Esko
6. T. Ju
7. S. Stowell
8. S. Nath

In Organic Chemistry

1. R. Cone
2. J. Esko
3. M. Fuster

Citations in the corpus

• Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2013, neutral): “Specifically, we chose the MUC4 gene on chromosome 3 that encodes a glycoprotein important for protecting mucus in diverse epithelial tissues and during tumor formation (Hollingsworth and Swanson, 2004).”
• Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress (2010, background): “Induction of Th2 cytokines, IL-4 and IL-13, caused expulsion of parasites such as Nocardia brasiliensis and Heligmosomoides hypogyrus from the intestinal lumen, by inducing RELMβ, which functions not only as Th2 cytokine immune effector molecule but also as an inhibitor of chemotaxis of parasites, i”
• Protein Glycosylation in Cancer (2015, background): “Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16.”
• MUC1: a multifaceted oncoprotein with a key role in cancer progression. (2014, background): “MUC1-N release induces conformational changes in MUC1-C that alter its ligand status and subsequently activates downstream cell signaling pathways such as the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3kinase (P13K/Akt), and wingless type (Wnt) pathways [43].”
• The sweet and sour of cancer: glycans as novel therapeutic targets (2005, background): “including cellular growth, differentiation, invasion and immune surveillance (reviewed in [20, 22]).”
• Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers (2011, background): “in the body within an individual [15]; long, branched oligosaccharide side chains on mucins may protect against proteolytic degradation by digestive proteases [16].”
• Respiratory tract mucin genes and mucin glycoproteins in health and disease. (2006, background): “They may entrap particles in the viscoelastic mucus gel, acting perhaps in conjunction with tethered mucins at the apical surface of epithelial cells (110), or bind receptors on inflammatory cells using motifs in specific MUC domains or in O-glycans.”