The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.
By J. Katz, N. Perreault, Bree G. Goldstein, Catherine S. Lee, P. Labosky, Vincent W. Yang, Klaus H. Kaestner. Development, 2002
620 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/a9ab802dd16ac04e5b6f341674465ce07170177e
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Citations in the corpus
- KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation (2004, background): “For example, KLF1/erythroid KLF is essential for red blood cell maturation (21, 22), whereas KLF4/gut KLF regulates the differentiation and maturation of dermal and gastrointestinal epithelial cells (23, 24).”
- Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent (2013, background): “Similarly, the amount of KLF4 protein, a transcription factor involved in goblet cell terminal differentiation [30], was higher in Bt-2d and Bt30d than GF rats (Figure 2D).”
- Krüppel-like factor 4 regulates macrophage polarization. (2011, methodology): “Klf4fl/fl mice were generated as described previously (55, 56).”
- Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. (2006, background): “Both Klf4 and c-Myc are dispensable for preimplantation mouse development (Baudino et al., 2002; Katz et al., 2002).”
- Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “2004), while differentiation of goblet cells is influenced by KLF4 (Katz et al. 2002).”
- Strategies and new developments in the generation of patient-specific pluripotent stem cells. (2007, background): “A conditional knockout mouse model suggests that KLF4 plays a role as a tumor suppressor in gastrointestinal cancers (Katz et al., 2005).”
- Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “Newborn Klf4 / mice also have a 90% reduction in the number of goblet cells in their colon, compared with wild-type controls (211), so KLF4 might regulate intestinal epithelial differentiation.”