Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

By C. Kraft, Anna Deplazes, M. Sohrmann, Matthias Peter. Nature Cell Biology, 2008

742 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/61d29d9d8afc4e267dfc2e9eba72a4dd254ba008

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Citations in the corpus

The many pathways of RNA degradation. (2009, background): “In addition, recent analyses reveal that under starvation conditions, mature ribosomes can be engulfed by the vacuole and degraded in a process that has been termed ‘‘ribophagy’’ due to its apparent similarities to the degradation of other cytoplasmic components by the autophagy pathway (Beau et al.”
Ribosomal proteins: functions beyond the ribosome. (2015, background): “Interestingly, it was found that RPs and the ribosome itself could be degraded in response to nutrient starvation (Kraft et al., 2008), leading to the severe impairment of ribosome assembly.”
Ubiquitination and selective autophagy (2012, background): “The deubiquitination activity of Ubp3/Bre5 is crucial for selective autophagy of excess ribosomes.(97) Similarly, selective autophagy of zymogen granules is dependent on the activity of the ubiquitin-specific protease USP9x.”
Large-scale inference of gene function through phylogenetic annotation of Gene Ontology terms: case study of the apoptosis and autophagy cellular processes (2016, background): “Depending on the cellular component targeted for recycling, the macroautophagy process is known as mitophagy for mitochondria degradation (20, 21), nucleophagy for nuclei degradation (22), pexophagy for peroxisomes breakdown (12, 23), ribophagy for ribosomes (24), reticulophagy for endoplasmic retic”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, methodology): “Autophagy is also used for the selective removal of ribosomes.(529) This process can be monitored by western blot, following the generation of free GFP from Rpl25-GFP or the disappearance of ribosomal subunits such as Rps3.”
Dynamics and diversity in autophagy mechanisms: lessons from yeast (2009, background): “In addition, cytoplasmic acetaldehyde dehydrogenase 6 (Ald6) and ribosomes are known to be preferentially degraded through autophagy under nitrogen starvation conditions, even though they seem to be completely dispersed in the cytoplasm, suggesting a novel mechanism for these case”
Molecular definitions of autophagy and related processes (2017, positive): “In yeast, ribophagy involves ribosomal de-ubiquitination by the mRNA-binding ubiquitin-specific protease Ubp3 and its cofactors Bre5, Doa1 (also known as Ufd3), and Cdc48 (Kraft et al , 2008; Ossareh-Nazari et al , 2010) and requires Atg11 (Waliullah et al , 2017).”
Autophagy during viral infection — a double-edged sword (2018, background): “According to the cargo, there are different types of autophagy: reticulophagy (endoplasmic reticulum) 97 , mitophagy (mitochondria) 166 , ribophagy (ribosomes) 167 and pexophagy (peroxisomes) 168 .”
Regulation Mechanisms and Signaling Pathways of Autophagy (2009, positive): “Different terms have been used to describe the selectivity of each process according to the cargo, such as autophagic degradation of mitochondria (mitophagy) (63), ribosomes (ribophagy) (73), peroxisomes (pexophagy) (25), and endoplasmic reticulum (ER; reticulophagy) (5,69).”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “The Rkr1/Ltn1 ubiquitin ligase acts as an inhibitor of 60S ribosomal subunit ribophagy via, at least, Rpl25 as a target, and is antagonized by the deubiquitinase Ubp3-Bre5 complex.(847,848) Rkr1/Ltn1 and Ubp3-Bre5 likely contribute to adapt ribophagy activity to both nutrient supply and protein tran”
Selective autophagy: ubiquitin-mediated recognition and beyond (2010, background): “Moreover, the selective degradation of excess ribosomes on nutrient starvation depends on the deubiquitylation activity of Ubp3/Bre5 (ref”