Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

By Hiroyuki Watanabe, J. Vriens, J. Prenen, G. Droogmans, T. Voets, B. Nilius. Nature, 2003

1,010 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Pharmacology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/60e268bb0105cba66a7f03d6b087b9d4bc972736

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. R. Pertwee
2. V. Di Marzo

In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. George Kunos
4. R. Ross
5. R. Mechoulam
6. K. Mackie
7. Allyn C. Howlett
8. P. Greasley

In Sensory Systems

1. B. Nilius
2. Ardem Patapoutian
3. G. Owsianik
4. R. Pertwee
5. Veena Viswanath
6. A. Dhaka
7. D. Clapham
8. M. Delling

Citations in the corpus

• TRP channels as cellular sensors (2003, background): “Expressed TRPV4 may be gated by epoxyeicosatrienoic acid”
• The TRP Superfamily of Cation Channels (2005, neutral): “5 ́6 ́-epoxyeicosatrienoic acid (5 ́6 ́-EET) (125, 126).”
• The transient receptor potential family of ion channels (2011, background): “Arachidonic­acid­ related compounds are involved in gating TRPV1 (arachidonoyl ethanolamide, 12,15­(S)­hydroperoxy eico­ sa tetraenoic acid and leukotriene B4 [94]) and TRPV4 (5’,6’­epoxieicosatrienoic acid [95]), and sphingosine, a primary part of sphingolipids, activates TRPM3 [96].”
• Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. (2004, neutral): “have been proposed to activate several ion channels, Calcium imaging experiments and oocyte electrophysiincluding TRPC3 and TRPV4, respectively (Clapham, ological recordings were undertaken to investigate 2003; Minke, 2001; Watanabe et al., 2003).”
• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, background): “TRPV4 was originally reported to be activated by anandamide and 2-AG, probably via the formation of cytochrome P450 metabolites of arachidonic acid, such as epoxyeicosatrienoic acids (Watanabe et al., 2003).”
• Trp ion channels and temperature sensation. (2006, background): “Other nonthermal activators of TRPV4 include anandamide, its metabolite arachidonic acid (AA), and the cytochrome P-450 metabolites of AA such as epoxyeicosatienoic acid (Watanabe et al. 2003).”
• TRP Channels (2012, neutral): “Activation of TRPV4 by AEA requires hydrolysis of AA by fatty acid aminohydrolase (FAAH) (469).”
• An introduction to TRP channels. (2006, background): “55-11μM ~2 agonist (66-72) I,Ca HEK NADA TRPV1 40nM agonist (66, 95) Ca HEK OLDA TRPV1 258nM agonist (95, 96) Ca HEK OEA TRPV1 2μM 1 agonist (97) I X PDDHV TRPV1 125nM agonist (98) B,Ca CHO PDDHV TRPV4 125nM agonist (99) I, Ca ? PPAHV TRPV1 157nM,667nM agonist (70, 96, 100-102) I, Ca HEK,CHO PI(4,5)”
• Phosphotidylinositol 4,5-Bisphosphate Signals Underlie Receptor-Specific Gq/11-Mediated Modulation of N-Type Ca2+ Channels (2004, background): “To this has been added direct actions of diacylglycerol and arachidonic acid (Bymaster et al., 1999; Hardie, 2003; Watanabe et al., 2003; Oliver et al., 2004).”