Effector memory T cells, early metastasis, and survival in colorectal cancer.

By Franck Pagès, A. Berger, M. Camus, Fátima Sánchez-Cabo, A. Costes, Robert Molidor, Bernhard Mlecnik, A. Kirilovsky, M. Nilsson, D. Damotte and 6 more. New England Journal of Medicine, 2005

2,124 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/608c79dfb95b1632f3cda7f427350880ee435e8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. L. Zitvogel
5. C. Garlanda
6. Oliver Kepp
7. Jérôme Galon
8. V. Bronte

In Oncology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. C. Garlanda
5. Jérôme Galon
6. L. Zitvogel
7. V. Bronte
8. George Coukos

Citations in the corpus

• Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours (2013, background): “Over the past few years, the area of immune regulation at the level of the tumour microenvironment has gained a forefront position in cancer research, in CRC [9,10,30,34,55], melanoma [67] and all other cancer types [7].”
• The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “(55, 56) have shown that the frequency of CD8(1) cells is a strong-positive prognostic indicator in colon cancer.”
• Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. (2008, background): “The density of tumorinfiltrating lymphocytes (TILs) with cytotoxic and memory phenotypes is highly predictive of good clinical outcome.(8-14) However, although prognosis is related to the homing of effector immune cells, it is still unclear where the activation of the specific immune response takes ”
• Molecular and genetic properties of tumors associated with local immune cytolytic activity (2015, positive): “However, given the importance of immune responses in controlling tumor progression (Pagè s et al., 2005), tumors may have evolved several mechanisms of evasion.”
• Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation (2021, background): “, by the observations that the presence of activated CD8T cells in cancers are associated with improved survival (20) and adoptive immunotherapy with T cells engineered to express TCRs from tumor-reactive CD8T cells can lead to cancer regression (21)].”
• Immune escape mechanisms as a guide for cancer immunotherapy (2014, background): “In colorectal carcinoma, high densities of CD8þ and CD45ROþ cells predicts decreased tumor recurrence and improved survival in patients with early-stage disease (38).”
• Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells (2011, background): “RESULTS RNS can modify chemokines in the tumor microenvironment Disease-free survival of patients with colorectal cancer strongly correlates with an increased ratio of T cells within the tumor relative to the tumor margins (Pagès et al., 2005; Galon et al., 2006).”
• Immunity, Inflammation, and Cancer (2010, neutral): “Indeed, in some cases, infiltration of tumors by activated T cells decreases the rate of metastasis (Galon et al., 2006; Pages et al., 2005).”
• Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma (2016, background): “Supporting this premise, CD45RO cell density was previously identified as an independent favorable prognostic factor in CRC (Nosho et al., 2010; Pagès et al., 2005).”