Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
By Jérôme Galon, Bernhard Mlecnik, Gabriela Bindea, H. Angell, A. Berger, C. Lagorce, A. Lugli, I. Zlobec, A. Hartmann, C. Bifulco and 38 more. Journal of Pathology, 2013
1,350 citations recorded by the source corpus.
The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression‐based stratification. These parameters rely on tumour‐cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named ‘Immunoscore’ has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM‐I (TNM‐Immune). © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Subfields: Oncology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/3aacb579b49b1c1d7f49562428d87e3e0dd892bb
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Citations in the corpus
- Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, result): “contrast to prior studies in CRC and other cancers, including lung, breast, ovarian and melanoma, in which relative abundances of these two cell types were correlated with outcome (Fridman et al., 2012; Galon et al., 2014; Galon et al., 2012; Pages et al., 2018).”
- The Acidic Tumor Microenvironment as a Driver of Cancer. (2019, background): “infiltration is an independent prognostic predictor in colorectal carcinomas (139).”
- Fusobacterium nucleatum and T-cells in Colorectal Carcinoma (2015, neutral): “48 Mutant 244 (41) 209 (40) 18 (50) 17 (45)”