Immune escape mechanisms as a guide for cancer immunotherapy

By G. Beatty, W. Gladney. Clinical Cancer Research, 2014

876 citations recorded by the source corpus.

Immunotherapy has demonstrated impressive outcomes for some patients with cancer. However, selecting patients who are most likely to respond to immunotherapy remains a clinical challenge. Here, we discuss immune escape mechanisms exploited by cancer and present strategies for applying this knowledge to improving the efficacy of cancer immunotherapy. Clin Cancer Res; 21(4); 687–92. ©2014 AACR.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/c1401dc28269c790f35f7e0299fe4f0b204cf4b4

Citations in the corpus

• Targeting FTO suppresses cancer stem cell maintenance and immune evasion (2020, neutral): “Evidence is emerging that tumor cells utilize ‘immune checkpoints’ as a major mechanism of immune evasion (Beatty and Gladney, 2015; Dong et al., 2002).”