Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

By M. Bibikova, D. Carroll, D. Segal, J. Trautman, Jeff Smith, Yang-Gyun Kim, S. Chandrasegaran. Molecular and Cellular Biology, 2001

629 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6058b38d01c74d401ee7b6734157d3134501a95a

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Citations in the corpus

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases (2008, background): “Cleavage at a given target site requires binding of two ZFNs in a specific spatial orientation relative to each other, that is, on opposite strands and separated by 5 or 6 bp to facilitate the dimerization of the Fok I domains necessary for DNA cleavag”
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling (2014, background): “…end-joining (NHEJ), resulting in insertions and deletions (indels) (Bibikova et al., 2002), or ho- mology-directed repair (HDR) (Bibikova et al., 2003; Bibikova et al., 2001; Jasin et al., 1985; Rudin et al., 1989), resulting in precise sequence substitution in the presence of a repair tem- plate.”
Genome editing with engineered zinc finger nucleases (2010, background): “The DSB is induced by a 'zinc finger nuclease' (ZFN”
Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification (2008, positive): “Because ZFNs can bind to sites in which two " half-sites " are separated by " spacer sequences " of five, six or seven base pairs (Bibikova et al., 2001; Porteus and Baltimore, 2003) (K. Wilson and M.H.P., unpublished data), one should be able to find approximately five full ZFN sites in any given…”
Genome Engineering With Zinc-Finger Nucleases (2011, background): “Several studies have shown that the optimum configuration uses a short linker between the domains of the protein and a spacer of 5 or 6 bp (7 can also work) between binding sites that lie in inverted orientation (Bibikova et al. 2001; Handel et al. 2009; Shimizu et al. 2009).”
Marker-free transgenic plants (2003, methodology): “This also indicates that Another sophisticated approach is to use tailorCre is capable of catalysing recombination between made endonucleases (Bibikova et al., 2001) designed certain naturally-occurring ‘pseudo-lox sites’ se- to induce DSBs at unique sites within the genome.”
Highly efficient endogenous human gene correction using designed zinc-finger nucleases (2005, background): “, demonstrated that the endonuclease I- Sce I can potentiate HR into loci previously engineered to contain its own recognition site, and the Carrol”
Development and Applications of CRISPR-Cas9 for Genome Engineering (2014, positive): “A series of studies by Haber and Jasin (Rudin et al., 1989; Plessis et al., 1992; Rouet et al., 1994; Choulika et al., 1995; Bibikova et al., 2001; Bibikova et al., 2003) led to the realization that tar- geted DNA double-strand breaks (DSBs) could greatly stimulate genome editing through HR-mediated”
Gene targeting using zinc finger nucleases (2005, background): “, subsequent studies, demonstrated that ZFNs cleave as dimer”