A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1

By C. Parham, M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, Rebecca Zhang, Komal P. Singh, F. Vega and 11 more. 2002

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IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis (2006, background): “The specifi city of this observation was confi rmed using IL-23R–defi cient mice (Fig.”
Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. (2009, background): “It has previously been reported that IL-23R is expressed on NK cells and memory T cells (Parham et al., 2002).”
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. (2007, methodology): “Identification of a second, unique IL-23 receptor subunit, which we named IL-23R, followed when we used a functional cloning strategy to isolate a cDNA that encoded a novel member of the IL-6/IL-12 cytokine receptor family (3).”
The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “…multiple sclerosis; PASI, psoriasis area and severity index; RA, rheumatoid arthritis; STAT, signal transducer and activator of transcription; TGF, transforming growth factor; Th, T helper; TNF, tumor necrosis factor to IL-23 (Belladonna et al., 2002; Parham et al., 2002; Rachitskaya et al., 2008).”