Dengue virus induced autophagy regulates lipid metabolism

By Nicholas S. Heaton, G. Randall. Cell Host and Microbe, 2010

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Summary Autophagy influences numerous cellular processes, including innate and adaptive immunity against intracellular pathogens. However, some viruses, including dengue virus (DENV), usurp autophagy to enhance their replication. The mechanism for a positive role of autophagy in DENV infection is unclear. We present data that DENV induction of autophagy regulates cellular lipid metabolism. DENV infection leads to an autophagy-dependent processing of lipid droplets and triglycerides to release free fatty acids. This results in an increase in cellular β-oxidation, which generates ATP. These processes are required for efficient DENV replication. Importantly, exogenous fatty acids can supplant the requirement of autophagy in DENV replication. These results define a role for autophagy in DENV infection and provide a mechanism by which viruses can alter cellular lipid metabolism to promote their replication.

Subfields: Epidemiology, Public Health, Environmental and Occupational Health, Virology

View Paper: https://www.semanticscholar.org/paper/f8a6eb9f7fe3cdd83ef1521dc38ac99f8da00146

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