Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

By B. Lustig, B. Jerchow, M. Sachs, Sigrid Weiler, T. Pietsch, U. Karsten, M. van de Wetering, Hans Clevers, P. Schlag, W. Birchmeier and 1 more. Molecular and Cellular Biology, 2002

1,124 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5fc848a04a4989e685a0c866f186d4b4d22ab29c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Xi He
4. S. Angers
5. K. Tamai
6. Z. Steinhart
7. A. Gregorieff
8. Toshiro Sato

Citations in the corpus

• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “While most Wnt target genes are cell-type- and developmental stage-specific, the Axin2 gene represents a generic transcriptional target gene, often used as indicator of canonical Wnt pathway activity (Lustig et al., 2002).”
• Wnt signaling and stem cell control (2008, background): “Because the expression of Axin2 is under the control of Wnt signaling in many tissues and Axin2 may even be a universal Wnt target, the reporter line made by Lustig et al. (2002) based on the Axin2 gene is very useful to visualize expression of the Wnt target in animals.”
• Nucleo-cytoplasmic distribution of β-catenin is regulated by retention (2006, background): “Intriguingly, the axin homologue axin2/conductin is a Wnt target itself (Jho et al., 2002; Lustig et al., 2002), thus possibly constituting a negative feedback factor that could limit the extent of Wnt signalling by retaining cytoplasmic -catenin.”
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way (2004, background): “In any event, one should keep in mind that, in mammalian cells, Wnt/βcatenin signaling induces the expression of an Axin homolog, Axin2 (also known as Axil/Conductin) (Behrens et al., 1998; Yamamoto et al., 1998; Yan et al., 2001; Jho et al., 2002; Leung et al., 2002; Lustig et al., 2002).”
• Wnt/β-catenin signaling and disease. (2012, positive): “Whereas most Wnt target genes are tissue or developmental stage specific, the Axin2 gene is generally regarded as a global transcriptional target and therefore a general indicator of Wnt pathway activity (Lustig et al., 2002).”
• Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “In normal cells, as part of a negative feedback mechanism, Axin2 is upregulated following Wnt stimulation (Jho et al. 2002; Leung et al. 2002; Lustig et al. 2002).”
• Wnt signaling in development and tissue homeostasis (2018, background): “Both Axin1 and Axin2 are functionally equivalent proteins (Chia and Costantini, 2005) but, in contrast to its paralog Axin1 , which is expressed constitutively, Axin2 is a Wnt target gene (Jho et al., 2002; Lustig et al., 2002).”
• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “Axin2 has emerged as one such Wnt target gene (23) that therefore serves as a reporter of ongoing Wnt signaling (24).”