Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms.

By K. Ishige, D. Schubert, Y. Sagara. Free Radical Biology & Medicine, 2001

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Fisetin is a senotherapeutic that extends health and lifespan (2018, background): “Fisetin has direct activity as a reducing agent, chemically reacting with and neutralizing reactive oxygen species [83,84].”
Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice (2017, neutral): “Due to it’s being hydrophobic, fisetin penetrates cell membranes and accumulates within cells to exert antioxidant effects [18].”
Ferroptosis: mechanisms and links with diseases (2021, background): “Interestingly, the lipophilic antioxidant α-toc can efficiently inhibit oxytosis.(154) Exogenous AA potentiates oxytotic cell death, while multiple Lox inhibitors can protect from GSH depletion.”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, neutral): “In a related study, flavonoids, natural plant compounds, were investigated (99).”
Cerium and yttrium oxide nanoparticles are neuroprotective. (2006, methodology): “These alternatives were sequentially ruled out by published procedures [25].”