daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.

By S. Henderson, T. Johnson. Current Biology, 2001

926 citations recorded by the source corpus.

Subfields: Aging

View Paper: https://www.semanticscholar.org/paper/5ec128236f4eae34848ab2c62dead6698d40c442

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. A. Brunet
3. T. Blackwell
4. E. L. Greer
5. L. Guarente
6. Coleen T. Murphy
7. G. Lithgow
8. Rute Martins

Citations in the corpus

• FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “In worms, flies, and mammalian cells, stress stimuli trigger the relocalization of FOXO to the nucleus (Henderson and Johnson, 2001; Lin et al., 2001; Wang et al., 2003; Brunet et al., 2004; Essers et al., 2004).”
• The C. elegans TGF-β Dauer Pathway Regulates Longevity via Insulin Signaling (2007, positive): “When daf-2 insulin receptor signaling is abrogated, DAF-16/FOXO becomes nuclearly localized [18, 19], and mutations in daf-18, the PTEN phosphatase that opposes insulin/PI-3-kinase signaling, promote cytoplasmic retention of DAF-16 [18].”
• FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK (2004, background): “In C. elegans, a variety of stresses including oxidative stress have been shown to induce translocation of DAF-16/ GFP from the cytosol to the nucleus (Henderson and Johnson, 2001).”
• Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007, background): “Moreover, DAF-16 regulates many stress-response genes (Honda & Honda, 1999; McElwee et al., 2003; Murphy et al., 2003) and DAF-16 is known to be activated by environmental stress (Henderson & Johnson, 2001; Lin et al., 2001).”
• p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, background): “How does the PMK-1 pathway interact with the DAF-2–DAF-16 pathway?”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “Heat shock triggers DAF-16 nuclear lotcalization (Henderson and Johnson, 2001; Lin et al., h2001), and DAF-16 is required for the full expression aof certain heat-shock genes, including the small heatwshock protein genes, following heat shock (Hsu et al., R2003).”
• SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. (2003, background): “…signaling reduces C. elegans lifespan by inhibiting the Foxo-type transcription factor DAF-16, which promotes longevity in part by increasing expression of ROS-resistance genes (Kenyon et al. 1993; Honda and Honda 1999; Finch and Ruvkun 2001; Henderson and Johnson 2001; Lee et al. 2003).”
• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “…mainly as transcriptional activators by binding the consensus core recognition motif TTGTTTAC, and their activity is inhibited by the IIS pathway (Biggs et al., 1999; Brunet et al., 1999; Henderson & Johnson, 2001; Lin et al., 2001; Calnan & Brunet, 2008; Zanella et al., 2010; Webb & Brunet, 2014).”
• An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, background): “Activated AMPK enhances FOXO/DAF-16-dependent transcription, perhaps via direct phosphorylation, leading to resistance to oxidative stress and longevity extension (Figure 7).”