Molecular mechanism of class switch recombination: linkage with somatic hypermutation.

By Tasuku Honjo, K. Kinoshita, M. Muramatsu. Annual Review of Immunology, 2002

624 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5eb2569dfa9d2b4a719726a2ed5e97db6443be15

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In Cardiology and Cardiovascular Medicine

Tasuku Honjo

In Molecular Biology

Citations in the corpus

Transcription-targeted DNA deamination by the AID antibody diversification enzyme (2003, background): “Similarly, although transcription of the target immunoglobulin locus sequences is required for both CSR and somatic hypermutation, the precise role of transcription has remained speculativ”
B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen (2011, background): “2b,c ), a hallmark of ongoing immunoglobulin gene diversification in germinal-center and some extrafollicular B cell”
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells (2004, background): “In addition, germinal-centre B cells undergo specific genome remodelling events, such as somatic hypermutation of multiple genes and CS”
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination (2003, background): “CSR and SHM processes share common steps: chromatin opening of the target regions (immunoglobulin switch (S) and variable (V) regions, respectively) associated with transcription, followed by DNA cleavage, repair and ligatio”
Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region (2002, background): “On the other hand, in CSR, two switch (S) regions located 5 to heavy-chain constant (C H ) region genes are cleaved and a large DNA fragment between the cleavages is excised out from the chromosome to bring in a downstream Ig C H region gene to the proximity of a rearranged V gene (7).”
Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. (2003, background): “However, the mechanism by which Vif prevents APOBEC3G encapsi- ulin isotype genes (Honjo et al., 2002).”
Induction of activation‐induced cytidine deaminase gene expression by IL‐4 and CD40 ligation is dependent on STAT6 and NFκB (2004, background): “One signal is delivered by cytokines and causes the transcription of specific isotype CH genes from promoters located upstream of the switch regions, targeting them for switch recombination (3,5, 6 ).”
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair (2004, background): “Therefore, CSR allows the expression of antibodies that have the same antigen specificity but are of a secondary IgH isotype (IgG, IgA or IgE) and thereby have a different effector functio”