Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

By K. Imai, G. Slupphaug, Wen-I. Lee, P. Revy, S. Nonoyama, Nadia Catalan, L. Yel, M. Forveille, B. Kavli, H. Krokan and 3 more. Nature Immunology, 2003

621 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/56aac6f9ed959756739a1bb4f62a24e0cd287b0d

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1. J. Stavnezer
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6. D. Hanahan

Citations in the corpus

• Repair and genetic consequences of endogenous DNA base damage in mammalian cells. (2004, background): “Mutations in the human UNG gene have been correlated with impaired class switch recombination in a subgroup of hyper-IgM syndrome patients (66); it has yet to be established if UNG-deficiency is associated with human B cell malignancies.”
• Mechanism and regulation of class switch recombination. (2008, background): “Some of the dU residues are excised by UNG, and some of the abasic sites are nicked by APE.”