Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.

By B. Popivanova, K. Kitamura, Yu Wu, T. Kondo, T. Kagaya, Shiuchi Kaneko, M. Oshima, C. Fujii, N. Mukaida. Journal of Clinical Investigation, 2008

926 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/5e04cd2407638336a504913ead620024964e8245

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. Karin
2. S. Grivennikov
3. A. Mantovani
4. F. Greten
5. S. Rose‐John
6. A. Sica
7. Sivakumar Vallabhapurapu
8. Y. Ben‐Neriah

In Genetics

1. M. Karin
2. F. Greten
3. S. Shalapour

In Immunology

1. M. Karin
2. A. Mantovani
3. A. Sica
4. P. Allavena
5. F. Balkwill
6. S. Grivennikov
7. C. Garlanda
8. F. Greten

Citations in the corpus

• Inflammation meets cancer, with NF-κB as the matchmaker (2011, background): “Many inflammatory cytokines, including TNF, IL-6 and IL-23, produced by lamina propria macrophages and dendritic cells, as well as by tumor-associated macrophages, have been identified as the main drivers of CAC growt”
• Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “…inactivation reduces tumor growth acting through activation of other oncogenic pathways in epithelial and cancer cells, including STAT3, ERK, JUN and receptor Tyr-kinases (RTK) (Becker et al., 2004; Grivennikov et al., 2009; Huber et al., 2012; Popivanova et al., 2008; Putoczki et al., 2013).”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “Tumor promotion by this cytokine can involve different pathways: TNF enhances tumor growth and invasion, leukocyte recruitment, angiogenesis and facilitate epithelial to mesenchymal transition [8,38,39].”
• Tumour necrosis factor and cancer (2009, background): “In both a chemically induced model of colorectal cancer and a genetic model of gastric cancer, macrophage-derived TNF was implicated in inflammation and subsequent tumour developmen”
• Chronic Inflammation and Cytokines in the Tumor Microenvironment (2014, neutral): “Interleukin 10 (IL-10).”
• IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer (2009, background): “CAC development and growth have been found to be attenuated in TNF receptor 1 (TNFR1) knockout mice or in mice treated with a soluble TNFR2 decoy (Enbrel) (Popivanova et al., 2008).”
• Mechanisms of Cisplatin Nephrotoxicity (2010, background): “Although TNF-α was named for its ability to induce hemorrhagic necrosis of tumors [220], there is increasing evidence that TNF-α is produced by cancer cells and acts as an endogenous tumor promoter [221–223].”
• Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “Genetic or pharmacological inhibition or intervention with these cytokines in various models of cancer either increases or decreases tumor growth and also affects tumormultiplicity [29,45,87–91].”