Tumour necrosis factor and cancer

By F. Balkwill. Nature Reviews. Cancer, 2009

1,975 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d75917c5588544c74c9b2bb9c3f629937e376df0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. Karin
2. Lisa M. Coussens
3. Zena Werb
4. D. Hanahan
5. A. Mantovani
6. S. Grivennikov
7. V. Plaks
8. F. Greten

In Immunology

1. A. Mantovani
2. M. Karin
3. A. Sica
4. Lisa M. Coussens
5. P. Allavena
6. D. Hanahan
7. F. Balkwill
8. C. Garlanda

In Molecular Biology

1. Lisa M. Coussens
2. Zena Werb
3. M. Karin
4. A. Mantovani
5. A. Sica
6. D. Hanahan
7. P. Allavena
8. S. Grivennikov

Citations in the corpus

• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “For example, tumour-associated macrophages were shown to induce sublethal oxidative stress in murine mammary tumour cells, possibly through the secretion of the inflammatory cytokine tumour necrosis factor-α (TNF-α) [42].”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “Tumor promotion by this cytokine can involve different pathways: TNF enhances tumor growth and invasion, leukocyte recruitment, angiogenesis and facilitate epithelial to mesenchymal transition [8,38,39].”
• Immunity, Inflammation, and Cancer (2010, background): “Although cytokine inhibitors alone are unlikely to cause cancer cell death, several phase I/II clinical trials currently evaluate the efficacy of anti-IL-6 and anti-TNFa drugs as single agents in various cancers (Balkwill, 2009).”
• The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “Although TNF-α can induce potent necrosis in tumors, it is also an important driver of inflammatory carcinogenesis (Balkwill, 2009).”
• Cancer-related inflammation: common themes and therapeutic opportunities. (2012, background): “[29]).”
• Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “All death receptors belong to TNFR superfamily (tumor necrosis factor receptor) [72].”
• Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “For example, given that TNF-α contributes to progression of several sorts of cancer (Balkwill, 2009), inhibiting TNF-α activation using MPIs might dampen the inflammatory milieu at the tumor microenvironment.”